2,4-difluoro-N-(2-methoxy-5-(5-(2-methyl-1-oxoisoindolin-5-yl)-thiophen-2-yl)pyridin-3-yl)benzenesulphonamide

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Chemical Name:2,4-difluoro-N-(2-methoxy-5-(5-(2-methyl-1-oxoisoindolin-5-yl)-thiophen-2-yl)pyridin-3-yl)benzenesulphonamide
CAS No.:1567836-83-2
Molecular Formula:C₂₅H₁₉F₂N₃O₄S₂
Molecular Weight:527.572
Hs Code.:

Synonyms:2,4-difluoro-N-(2-methoxy-5-(5-(2-methyl-1-oxoisoindolin-5-yl)-thiophen-2-yl)pyridin-3-yl)benzenesulphonamide

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Chemical Property of 2,4-difluoro-N-(2-methoxy-5-(5-(2-methyl-1-oxoisoindolin-5-yl)-thiophen-2-yl)pyridin-3-yl)benzenesulphonamide

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Technology Process of 2,4-difluoro-N-(2-methoxy-5-(5-(2-methyl-1-oxoisoindolin-5-yl)-thiophen-2-yl)pyridin-3-yl)benzenesulphonamide

There total 5 articles about 2,4-difluoro-N-(2-methoxy-5-(5-(2-methyl-1-oxoisoindolin-5-yl)-thiophen-2-yl)pyridin-3-yl)benzenesulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1567836-83-2
2,4-difluoro-N-(2-methoxy-5-(5-(2-methyl-1-oxoisoindolin-5-yl)-thiophen-2-yl)pyridin-3-yl)benzenesulphonamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In ethanol; toluene; at 105 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1083326-73-1
N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

: 1567836-36-5
5-(5-iodothiophen-2-yl)-2-methylisoindolin-1-one

: 1567836-83-2
2,4-difluoro-N-(2-methoxy-5-(5-(2-methyl-1-oxoisoindolin-5-yl)-thiophen-2-yl)pyridin-3-yl)benzenesulphonamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In ethanol; toluene; for 2h; Reflux;
DOI:10.1016/j.ejmech.2017.05.048

Reference yield:

: 13918-92-8
2,4-difluorobenzene-1-sulfonyl chloride

: 1567836-83-2
2,4-difluoro-N-(2-methoxy-5-(5-(2-methyl-1-oxoisoindolin-5-yl)-thiophen-2-yl)pyridin-3-yl)benzenesulphonamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 20 - 45 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 4 h / Reflux; Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / ethanol; toluene / 2 h / Reflux

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; In ethanol; dichloromethane; dimethyl sulfoxide; toluene; 2: |Suzuki Coupling / 3: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2017.05.048