5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydroquinolin-3-carboxamide

Base Information

Chemical Name:5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydroquinolin-3-carboxamide
CAS No.:1429439-47-3
Molecular Formula:C₃₄H₃₈ClN₃O₆
Molecular Weight:620.145
Hs Code.:

Synonyms:5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydroquinolin-3-carboxamide

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Chemical Property of 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydroquinolin-3-carboxamide

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Technology Process of 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydroquinolin-3-carboxamide

There total 6 articles about 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydroquinolin-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.9%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 1429439-24-6
5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

: 1429439-47-3
5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydroquinolin-3-carboxamide

Guidance literature:: 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

1-(2-aminoethyl)pyrrolidine; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 51624-70-5
5-ethyl-9-nitro-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-a]quinolin-7-carboxylic acid

: 1429439-47-3
5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydroquinolin-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; palladium on activated charcoal; hydrogen; acetic acid / 1 h / 2585.81 Torr

2.1: hydrogenchloride; sodium nitrite / water / 5 h / 20 - 45 °C / Inert atmosphere

3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

4.1: water; potassium hydroxide / methanol / 1.5 h / Inert atmosphere; Reflux

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

5.2: 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; palladium on activated charcoal; water; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; potassium iodide; potassium hydroxide; sodium nitrite; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 80104-60-5
5-chloro-6,7-dihydroxy-1,4-dihydro-1-ethyl-4-oxoquinoline-3-carboxylic acid

: 1429439-47-3
5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydroquinolin-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

2.1: water; potassium hydroxide / methanol / 1.5 h / Inert atmosphere; Reflux

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium iodide; potassium hydroxide; In methanol; N,N-dimethyl-formamide;