Technology Process of 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydroquinolin-3-carboxamide
There total 6 articles about 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydroquinolin-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;
With
N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
Inert atmosphere;
1-(2-aminoethyl)pyrrolidine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride; palladium on activated charcoal; hydrogen; acetic acid / 1 h / 2585.81 Torr
2.1: hydrogenchloride; sodium nitrite / water / 5 h / 20 - 45 °C / Inert atmosphere
3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere
4.1: water; potassium hydroxide / methanol / 1.5 h / Inert atmosphere; Reflux
5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere
5.2: 1 h / 20 °C / Inert atmosphere
With
hydrogenchloride; palladium on activated charcoal; water; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; potassium iodide; potassium hydroxide; sodium nitrite;
In
methanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere
2.1: water; potassium hydroxide / methanol / 1.5 h / Inert atmosphere; Reflux
3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere
3.2: 1 h / 20 °C / Inert atmosphere
With
water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium iodide; potassium hydroxide;
In
methanol; N,N-dimethyl-formamide;