6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-5-methylnicotinic acid

Base Information

Chemical Name:6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-5-methylnicotinic acid
CAS No.:901300-13-8
Molecular Formula:C₂₅H₂₅N₃O₅
Molecular Weight:447.491
Hs Code.:

Synonyms:6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-5-methylnicotinic acid

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Chemical Property of 6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-5-methylnicotinic acid

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Technology Process of 6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-5-methylnicotinic acid

There total 1 articles about 6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-5-methylnicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 617703-01-2
N-(2-(tert-butoxycarbonylamino)phenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

: 901300-51-4
6-bromo-5-methyl-3-pyridinecarboxylic acid

: 901300-13-8
6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-5-methylnicotinic acid

Guidance literature:: N-(2-(tert-butoxycarbonylamino)phenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 6-bromo-5-methyl-3-pyridinecarboxylic acid; With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 17 - 80 ℃; for 2h;

With hydrogenchloride; water; pH=3;

Reference yield:

: 901300-13-8
6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-5-methylnicotinic acid

: 108-00-9
N,N-dimethylethylenediamine

: C₂₉H₃₅N₅O₄

Guidance literature:: 6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-5-methylnicotinic acid; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 17 - 25 ℃; for 2h;

N,N-dimethylethylenediamine; With pyridine; In dichloromethane; at 17 - 25 ℃; for 18h;

Reference yield:

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 901300-13-8
6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-5-methylnicotinic acid

: C₃₁H₃₇N₅O₄

Guidance literature:: 6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-5-methylnicotinic acid; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 17 - 25 ℃; for 2h;

1-(2-aminoethyl)pyrrolidine; With pyridine; In dichloromethane; at 20 ℃; for 72h;