Technology Process of (R)-N-4-Benzyl-2-phenylpiperazine
There total 5 articles about (R)-N-4-Benzyl-2-phenylpiperazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
glucose-6-phosphate dehydrogenase; glucose-6-phosphate; Myxococcus stipitatus R-selective imine reductase; NADPH; magnesium chloride;
In
aq. phosphate buffer;
at 25 ℃;
for 4h;
pH=7;
Enzymatic reaction;
DOI:10.1021/acscatal.8b00291
- Guidance literature:
-
With
methanol; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate;
In
acetonitrile;
at 20 ℃;
for 3h;
Schlenk technique;
Inert atmosphere;
Irradiation;
Green chemistry;
DOI:10.1021/acs.orglett.0c01759
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: borane-THF / tetrahydrofuran / 5 h / -10 °C / Inert atmosphere
1.2: 18 h / -10 - 20 °C / Inert atmosphere
2.1: dichloromethane / 2 h / 0 - 20 °C
3.1: potassium hydroxide / methanol / 0.5 h / 20 °C / Schlenk technique; Inert atmosphere; Green chemistry
4.1: (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; methanol / acetonitrile / 3 h / 20 °C / Schlenk technique; Inert atmosphere; Irradiation; Green chemistry
With
methanol; borane-THF; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; potassium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/acs.orglett.0c01759