1-Benzyl-3-phenylpiperazine

Base Information

• Chemical Name: 1-Benzyl-3-phenylpiperazine
• CAS No.: 5368-32-1
• Molecular Formula: C17H20 N2
• Molecular Weight: 252.359
• Hs Code.: 2933599090
• European Community (EC) Number: 688-054-7
• DSSTox Substance ID: DTXSID50590507
• Mol file: 5368-32-1.mol

Synonyms:1-benzyl-3-phenylpiperazine;5368-32-1;(R)-N-4-Benzyl-2-phenylpiperazine;(S)-1-benzyl-3-phenylpiperazine;1-N-Benzyl-3-phenylpiperazine;SCHEMBL3272931;DTXSID50590507;MFCD07367740;AKOS005255366;AB45017;Piperazine,3-phenyl-1-(phenylmethyl)-;SB12549;SB12550;WS-01266;DB-019299;DB-071138;CS-0183214;A26362;EN300-235231;W18940;F2147-0816

Chemical Property of 1-Benzyl-3-phenylpiperazine

Chemical Property:

• Vapor Pressure: 3.58E-06mmHg at 25°C
• Boiling Point: 386.3°Cat760mmHg
• Flash Point: 156°C
• PSA: 15.27000
• Density: 1.069g/cm³
• LogP: 3.09980
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 252.162648646
• Heavy Atom Count: 19
• Complexity: 254

Purity/Quality:

97% ^*data from raw suppliers

1-Benzyl-3-phenylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CC(N1)C2=CC=CC=C2)CC3=CC=CC=C3

Technology Process of 1-Benzyl-3-phenylpiperazine

There total 5 articles about 1-Benzyl-3-phenylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylglyoxal hydrate (1074-12-0) + N-benzylethylenediamine (4152-09-4) → 1-benzyl-3-(phenyl)piperazine (5368-32-1,502482-38-4)

Guidance literature:

With glucose-6-phosphate dehydrogenase; glucose-6-phosphate; Myxococcus stipitatus R-selective imine reductase; NADPH; magnesium chloride; In aq. phosphate buffer; at 25 ℃; for 4h; pH=7; Enzymatic reaction;

DOI:10.1021/acscatal.8b00291

Reference yield:

C18H20N2O2 → 1-benzyl-3-(phenyl)piperazine (5368-32-1,502482-38-4)

Guidance literature:

With methanol; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; In acetonitrile; at 20 ℃; for 3h; Schlenk technique; Inert atmosphere; Irradiation; Green chemistry;

DOI:10.1021/acs.orglett.0c01759

Reference yield:

tert-butyl N-benzyl-N-((tert-butoxycarbonyl)glycyl)glycinate → 1-benzyl-3-(phenyl)piperazine (5368-32-1,502482-38-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 5 h / -10 °C / Inert atmosphere

1.2: 18 h / -10 - 20 °C / Inert atmosphere

2.1: dichloromethane / 2 h / 0 - 20 °C

3.1: potassium hydroxide / methanol / 0.5 h / 20 °C / Schlenk technique; Inert atmosphere; Green chemistry

4.1: (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; methanol / acetonitrile / 3 h / 20 °C / Schlenk technique; Inert atmosphere; Irradiation; Green chemistry

With methanol; borane-THF; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

DOI:10.1021/acs.orglett.0c01759

upstream raw materials:

phenylglyoxal hydrate

N-benzylethylenediamine

tert-butyl 2-(benzylamino)acetate

Downstream raw materials:

C₂₈H₂₇N₃O₂

C₃₁H₂₈N₄O₃S

C₂₈H₂₇N₃O

C₂₇H₂₅N₃O

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 5368-32-1 (R)-N-4-Benzyl-2-phenylpiperazine

Send

Send

Metric Ton KG G Pound L ML

Send

Send