8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(4-nitrobenzyloxycarbonylamino)octanamide

Base Information

Chemical Name:8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(4-nitrobenzyloxycarbonylamino)octanamide
CAS No.:119860-18-3
Molecular Formula:C₂₄H₂₈F₂N₄O₈
Molecular Weight:538.505
Hs Code.:

Synonyms:8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(4-nitrobenzyloxycarbonylamino)octanamide

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Chemical Property of 8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(4-nitrobenzyloxycarbonylamino)octanamide

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Technology Process of 8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(4-nitrobenzyloxycarbonylamino)octanamide

There total 6 articles about 8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(4-nitrobenzyloxycarbonylamino)octanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 119860-17-2
8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(R,S)-(4-nitrobenzyloxycarbonylamino) octanoic acid ethyl ester

: 119860-18-3
8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(4-nitrobenzyloxycarbonylamino)octanamide

Guidance literature:: With ammonia; In diethyl ether; at -78 ℃;
DOI:10.1016/0040-4020(95)00896-G

Reference yield: 70.0%

: 119860-17-2,138802-26-3,138802-27-4
(S)-8-Benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(4-nitro-benzyloxycarbonylamino)-octanoic acid ethyl ester

: 119860-18-3
[(S)-7-Carbamoyl-7,7-difluoro-6-hydroxy-5-(4-nitro-benzyloxycarbonylamino)-heptyl]-carbamic acid benzyl ester

Guidance literature:: With ammonia; In diethyl ether; from -78 deg C to r.t.;
DOI:10.1016/S0040-4039(00)82154-1

Reference yield:

: 138802-24-1
(R,S)-1-formyl-1-(4-nitrobenzyl)-5-benzylpentylene dicarbamate

: 119860-18-3
8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(4-nitrobenzyloxycarbonylamino)octanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) zinc, iodine / 1.) THF, rt, 15 min, ultrasonication; 2.) THF, rt, 35 min, ultrasonication

2: 89 percent / ammonia gas / diethyl ether / -78 °C

With ammonia; iodine; zinc; In diethyl ether;
DOI:10.1016/0040-4020(95)00896-G