8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(R,S)-(4-nitrobenzyloxycarbonylamino) octanoic acid ethyl ester

Base Information

Chemical Name:8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(R,S)-(4-nitrobenzyloxycarbonylamino) octanoic acid ethyl ester
CAS No.:119860-17-2
Molecular Formula:C₂₆H₃₁F₂N₃O₉
Molecular Weight:567.544
Hs Code.:

Synonyms:8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(R,S)-(4-nitrobenzyloxycarbonylamino) octanoic acid ethyl ester

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Chemical Property of 8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(R,S)-(4-nitrobenzyloxycarbonylamino) octanoic acid ethyl ester

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Technology Process of 8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(R,S)-(4-nitrobenzyloxycarbonylamino) octanoic acid ethyl ester

There total 5 articles about 8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(R,S)-(4-nitrobenzyloxycarbonylamino) octanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 119860-17-2
8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(R,S)-(4-nitrobenzyloxycarbonylamino) octanoic acid ethyl ester

Guidance literature:

Reference yield:

: N-α-(4-nitrobenzyloxycarbonyl)-N-ε-benzyloxycarbonyl lysine methyl ester

: 119860-17-2
8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(R,S)-(4-nitrobenzyloxycarbonylamino) octanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / diisobutylaluminium hydride / diethyl ether; toluene; hexane / 0.17 h / -78 °C

2: 1.) zinc, iodine / 1.) THF, rt, 15 min, ultrasonication; 2.) THF, rt, 35 min, ultrasonication

With iodine; diisobutylaluminium hydride; zinc; In diethyl ether; hexane; toluene;
DOI:10.1016/0040-4020(95)00896-G

Reference yield:

: 119860-15-0
(S)-6-Benzyloxycarbonylamino-2-(4-nitro-benzyloxycarbonylamino)-hexanoic acid methyl ester

: 119860-17-2,138802-26-3,138802-27-4
(S)-8-Benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(4-nitro-benzyloxycarbonylamino)-octanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride

2: Zn / tetrahydrofuran

With diisobutylaluminium hydride; zinc; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)82154-1