4-amino-1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methoxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one

Base Information

Chemical Name:4-amino-1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methoxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one
CAS No.:851346-07-1
Molecular Formula:C₃₄H₅₁N₃O₅Si₂
Molecular Weight:637.967
Hs Code.:

4-amino-1-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-5-methoxymethyl-tetrahydro-furan-2-yl]-5-methyl-1<i>H</i>-pyrimidin-2-one

Synonyms:4-amino-1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methoxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one

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Chemical Property of 4-amino-1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methoxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one

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Technology Process of 4-amino-1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methoxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one

There total 3 articles about 4-amino-1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methoxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,4,6-triisopropyl-benzenesulfonic acid 1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methoxymethyl-tetrahydro-furan-2-yl]-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

: 851346-07-1
4-amino-1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methoxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one

Guidance literature:: With ammonium hydroxide; In acetonitrile; at 0 - 20 ℃; for 3h;
DOI:10.1002/chem.200401114

Reference yield:

: 851345-90-9
3'-O-tert-butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-4'-C-methoxymethylenethymidine

: 851346-07-1
4-amino-1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methoxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: DMAP; Et₃N / acetonitrile / 1.5 h / 0 °C

2: 71 mg / NH₄OH / acetonitrile / 3 h / 0 - 20 °C

With dmap; ammonium hydroxide; triethylamine; In acetonitrile;
DOI:10.1002/chem.200401114

Reference yield:

: 162052-67-7
1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 851346-07-1
4-amino-1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-methoxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

1.2: 75 percent / tetrahydrofuran / 10 h / 0 °C

2.1: DMAP; Et₃N / acetonitrile / 1.5 h / 0 °C

3.1: 71 mg / NH₄OH / acetonitrile / 3 h / 0 - 20 °C

With dmap; ammonium hydroxide; sodium hydride; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1002/chem.200401114