2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-(4-bromophenyl)ethanone

Base Information

• Chemical Name: 2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-(4-bromophenyl)ethanone
• CAS No.: 1380395-63-0
• Molecular Formula: C₁₅H₁₁BrN₄O₂S
• Molecular Weight: 391.248
• Mol file: 1380395-63-0.mol

Synonyms:2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-(4-bromophenyl)ethanone

Chemical Property of 2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-(4-bromophenyl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-(4-bromophenyl)ethanone

There total 4 articles about 2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-(4-bromophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C7H6N4OS (917462-04-5) + para-bromophenacyl bromide (99-73-0,132309-76-3) → 2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-(4-bromophenyl)ethanone (1380395-63-0)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃;

DOI:10.1016/j.bmc.2012.03.061

Reference yield: 87.0%

→ 2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-(4-bromophenyl)ethanone (1380395-63-0)

Guidance literature:

In ethanol; at 20 ℃;

Reference yield:

methyl 2-aminoisonicotinate (6937-03-7) → 2-(5-(2-aminopyridin-4-yl)-1,3,4-oxadiazol-2-ylthio)-1-(4-bromophenyl)ethanone (1380395-63-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrazine hydrate / ethanol / Reflux

2.1: potassium hydroxide / ethanol / 24 h / Reflux

2.2: pH 5 - 6

3.1: sodium hydroxide / ethanol; water / 20 °C

With hydrazine hydrate; potassium hydroxide; sodium hydroxide; In ethanol; water;

DOI:10.1016/j.bmc.2012.03.061

upstream raw materials:

methyl 2-aminoisonicotinate

C₇H₆N₄OS

para-bromophenacyl bromide

2-aminoisonicotinic acid hydrazide