7-bromo-5-fluoroquinazolin-2-amine

Base Information

• Chemical Name: 7-bromo-5-fluoroquinazolin-2-amine
• CAS No.: 1379341-83-9
• Molecular Formula: C₈H₅BrFN₃
• Molecular Weight: 242.05
• Mol file: 1379341-83-9.mol

Synonyms:7-bromo-5-fluoroquinazolin-2-amine

Chemical Property of 7-bromo-5-fluoroquinazolin-2-amine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

7-Bromo-5-Fluoroquinazolin-2-Amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-bromo-5-fluoroquinazolin-2-amine

There total 2 articles about 7-bromo-5-fluoroquinazolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-bromo-2,6-difluorobenzaldehyde (537013-51-7) + guanidine bis(carbonate) (124-46-9,593-85-1,20734-13-8,100224-74-6,90332-86-8,3425-08-9) → 7-bromo-5-fluoroquinazolin-2-amine (1379341-83-9)

Guidance literature:

In N,N-dimethyl acetamide; at 30 - 140 ℃; for 4.5h; Inert atmosphere; Cooling with ice;

Reference yield: 77.6%

guanidine carbonate (593-85-1,90332-86-8,3425-08-9) + 4-bromo-2,6-difluorobenzaldehyde (537013-51-7) → 7-bromo-5-fluoroquinazolin-2-amine (1379341-83-9)

Guidance literature:

In N,N-dimethyl acetamide; at 150 ℃; for 4h;

Reference yield: 40.1%

7-bromo-5-fluoroquinazolin-2-amine (1379341-83-9) + phenyl chloroformate (1885-14-9) → phenyl N‐(7‐bromo‐5‐fluoroquinazolin‐2‐yl)carbamate

Guidance literature:

7-bromo-5-fluoroquinazolin-2-amine; With potassium carbonate; In tetrahydrofuran; water; at 60 ℃; for 0.166667h;

phenyl chloroformate; In tetrahydrofuran; water; at 20 ℃;

upstream raw materials:

4-bromo-2,6-difluorobenzaldehyde

guanidine bis(carbonate)

guanidine carbonate

Refernces

• 1、 -. "QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS". Paragraph 00295. . Retrieved 2013/03/26.