methyl 2-[(S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido]benzoate

Base Information

• Chemical Name: methyl 2-[(S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido]benzoate
• CAS No.: 119422-34-3
• Molecular Formula: C₁₉H₂₈N₂O₅
• Molecular Weight: 364.442
• Mol file: 119422-34-3.mol

Synonyms:methyl 2-[(S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido]benzoate

Chemical Property of methyl 2-[(S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 2-[(S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido]benzoate

There total 1 articles about methyl 2-[(S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + 2-carbomethoxyaniline (134-20-3) → methyl 2-[(S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido]benzoate (119422-34-3)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 12.2h;

DOI:10.1002/ejoc.201201739

Reference yield:

methyl 2-[(S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido]benzoate (119422-34-3) → C18H26N2O5

Guidance literature:

methyl 2-[(S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido]benzoate; With lithium hydroxide monohydrate; In methanol; water; at 0 - 20 ℃; for 4h;

With potassium hydrogensulfate; In water;

DOI:10.1002/ejoc.201201739

Reference yield:

methyl 2-[(S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido]benzoate (119422-34-3) → tert-butyl (2S)-1-{2-[2-(4-bromophenylcarbamoyl)pyrrolidine-1-carbonyl]phenylamino}-4-methyl-1-oxopentan-2-ylcarbamate

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / methanol; water / 4 h / 0 - 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

With dmap; lithium hydroxide monohydrate; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water;

DOI:10.1002/ejoc.201201739

upstream raw materials:

N-tert-butoxycarbonyl-L-leucine

2-carbomethoxyaniline