(rac)-4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol

Base Information

Chemical Name:(rac)-4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol
CAS No.:1469979-58-5
Molecular Formula:C₁₅H₁₁F₄NO
Molecular Weight:297.252
Hs Code.:

Synonyms:(rac)-4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (rac)-4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol

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Technology Process of (rac)-4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol

There total 5 articles about (rac)-4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1469979-93-8
4-(3-fluoro-4-trifluoromethylphenyl)-5,6-dihydro-7H-cyclopenta[c]pyridin-7-one

: 1469979-58-5
(rac)-4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; Inert atmosphere;
DOI:10.1039/c6ob00848h

Reference yield: 55.0%

: 1469979-58-5
(rac)-4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; at 85 ℃; Inert atmosphere;

Reference yield:

: 1445218-36-9
5-(3-fluoro-4-trifluoromethyl-phenyl)-oxazole

: 1469979-58-5
(rac)-4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / toluene / 2 h / 230 °C / 38787.1 Torr / Microwave irradiation

2: tert.-butylhydroperoxide; dirhodium(II)tetrakis-(caprolactam); sodium hydrogencarbonate / dichloromethane / 48 h / 20 °C

3: sodium tetrahydroborate / methanol / 0 °C / Inert atmosphere

With tert.-butylhydroperoxide; sodium tetrahydroborate; dirhodium(II)tetrakis-(caprolactam); sodium hydrogencarbonate; trifluoroacetic acid; In methanol; dichloromethane; toluene;
DOI:10.1039/c6ob00848h