4-[3-fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridine

Base Information

Chemical Name:4-[3-fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridine
CAS No.:1445218-26-7
Molecular Formula:C₁₅H₁₁F₄N
Molecular Weight:281.253
Hs Code.:

Synonyms:4-[3-fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridine

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Chemical Property of 4-[3-fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridine

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Technology Process of 4-[3-fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridine

There total 2 articles about 4-[3-fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1445218-36-9
5-(3-fluoro-4-trifluoromethyl-phenyl)-oxazole

: 142-29-0
cyclopentene

: 1445218-26-7
4-[3-fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridine

Guidance literature:: With trifluoroacetic acid; In toluene; at 230 ℃; for 2h; under 38787.1 Torr; Flow reactor;
DOI:10.1021/ol4013525

Reference yield:

: 204339-72-0
3-fluoro-4-trifluoromethyl-benzaldehyde

: 1445218-26-7
4-[3-fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 14 h / Inert atmosphere; Reflux

2: trifluoroacetic acid / toluene / 230 °C / Inert atmosphere

With potassium carbonate; trifluoroacetic acid; In methanol; toluene; 2: |Diels-Alder Cycloaddition;

Reference yield: 22.0%

: 1445218-26-7
4-[3-fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridine

: 1469979-93-8
4-(3-fluoro-4-trifluoromethylphenyl)-5,6-dihydro-7H-cyclopenta[c]pyridin-7-one

: 4-(3-fluoro-4-trifluoromethyl-phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-5-one

Guidance literature:: With tert.-butylhydroperoxide; tetrakis(μ-caprolactamato)dirhodium(Rh-Rh); sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;