(-)-[(4R,5R)-2,2-dimethyl-5-((R)-2,2,2-trifluoro-1-phenyl-1-(trimethylsilanyloxy)ethyl)-[1,3]dioxolan-4-yl]phenylmethanone

Base Information

Chemical Name:(-)-[(4R,5R)-2,2-dimethyl-5-((R)-2,2,2-trifluoro-1-phenyl-1-(trimethylsilanyloxy)ethyl)-[1,3]dioxolan-4-yl]phenylmethanone
CAS No.:929217-56-1
Molecular Formula:C₂₃H₂₇F₃O₄Si
Molecular Weight:452.546
Hs Code.:

Synonyms:(-)-[(4R,5R)-2,2-dimethyl-5-((R)-2,2,2-trifluoro-1-phenyl-1-(trimethylsilanyloxy)ethyl)-[1,3]dioxolan-4-yl]phenylmethanone

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Chemical Property of (-)-[(4R,5R)-2,2-dimethyl-5-((R)-2,2,2-trifluoro-1-phenyl-1-(trimethylsilanyloxy)ethyl)-[1,3]dioxolan-4-yl]phenylmethanone

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Technology Process of (-)-[(4R,5R)-2,2-dimethyl-5-((R)-2,2,2-trifluoro-1-phenyl-1-(trimethylsilanyloxy)ethyl)-[1,3]dioxolan-4-yl]phenylmethanone

There total 3 articles about (-)-[(4R,5R)-2,2-dimethyl-5-((R)-2,2,2-trifluoro-1-phenyl-1-(trimethylsilanyloxy)ethyl)-[1,3]dioxolan-4-yl]phenylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 167282-09-9
(-)-((4R,5R)-5-benzoyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-phenyl-methanone

: 929217-56-1
(-)-[(4R,5R)-2,2-dimethyl-5-((R)-2,2,2-trifluoro-1-phenyl-1-(trimethylsilanyloxy)ethyl)-[1,3]dioxolan-4-yl]phenylmethanone

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -40 ℃; for 1h;
DOI:10.1021/jo062016z

Reference yield: 54.0%

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 167282-09-9
(-)-((4R,5R)-5-benzoyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-phenyl-methanone

: 929217-56-1
(-)-[(4R,5R)-2,2-dimethyl-5-((R)-2,2,2-trifluoro-1-phenyl-1-(trimethylsilanyloxy)ethyl)-[1,3]dioxolan-4-yl]phenylmethanone

: 2,2-dimethyl-4,5-bis-(2,2,2-trifluoro-1-phenyl-1-trimethylsilanyloxy-ethyl)-[1,3]dioxolane

Guidance literature:: With cesium fluoride; In 1,2-dimethoxyethane; at 20 ℃; for 12h;
DOI:10.1021/jo062016z

Reference yield:

: 177283-77-1
(4R,5R)-N,N'-dimethoxy-N,N',2,2-tetramethyl-1,3-dioxolane-4,5-dicarboxamide

: 929217-56-1
(-)-[(4R,5R)-2,2-dimethyl-5-((R)-2,2,2-trifluoro-1-phenyl-1-(trimethylsilanyloxy)ethyl)-[1,3]dioxolan-4-yl]phenylmethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / tetrahydrofuran / 3 h / 0 °C

2: 90 percent / tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 1 h / -40 °C

With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/jo062016z