2,6-anhydro-1-O-benzyl-5-deoxy-5-fluoro-3,4-O-isopropylidene-D-arabino-hex-5-enitol

Base Information

• Chemical Name: 2,6-anhydro-1-O-benzyl-5-deoxy-5-fluoro-3,4-O-isopropylidene-D-arabino-hex-5-enitol
• CAS No.: 1064036-17-4
• Molecular Formula: C₁₆H₁₉FO₄
• Molecular Weight: 294.323
• Mol file: 1064036-17-4.mol

Synonyms:2,6-anhydro-1-O-benzyl-5-deoxy-5-fluoro-3,4-O-isopropylidene-D-arabino-hex-5-enitol

Chemical Property of 2,6-anhydro-1-O-benzyl-5-deoxy-5-fluoro-3,4-O-isopropylidene-D-arabino-hex-5-enitol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-anhydro-1-O-benzyl-5-deoxy-5-fluoro-3,4-O-isopropylidene-D-arabino-hex-5-enitol

There total 1 articles about 2,6-anhydro-1-O-benzyl-5-deoxy-5-fluoro-3,4-O-isopropylidene-D-arabino-hex-5-enitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-anhydro-5-deoxy-5-fluoro-3,4-O-isopropylidene-D-arabino-hex-5-enitol (1064036-15-2) + benzyl bromide (100-39-0) → 2,6-anhydro-1-O-benzyl-5-deoxy-5-fluoro-3,4-O-isopropylidene-D-arabino-hex-5-enitol (1064036-17-4)

Guidance literature:

2,6-anhydro-5-deoxy-5-fluoro-3,4-O-isopropylidene-D-arabino-hex-5-enitol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

benzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

DOI:10.1002/chem.200800734

Reference yield: 79.0%

2,6-anhydro-1-O-benzyl-5-deoxy-5-fluoro-3,4-O-isopropylidene-D-arabino-hex-5-enitol (1064036-17-4) → 6-O-benzyl-2-deoxy-2-fluoro-3,4-O-isopropylidene-2-iodo-D-galactopyranose

Guidance literature:

With N-iodo-succinimide; water; In tetrahydrofuran; at 20 ℃; Darkness;

DOI:10.1002/chem.200800734

Reference yield: 55.0%

2,6-anhydro-1-O-benzyl-5-deoxy-5-fluoro-3,4-O-isopropylidene-D-arabino-hex-5-enitol (1064036-17-4) → 6-O-benzyl-2-bromo-2-deoxy-2-fluoro-3,4-O-isopropylidene-D-galactopyranose

Guidance literature:

With N-Bromosuccinimide; water; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/chem.200800734

upstream raw materials:

2,6-anhydro-5-deoxy-5-fluoro-3,4-O-isopropylidene-D-arabino-hex-5-enitol

benzyl bromide