(3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-4,5,8,8a-tetrahydro-3aH-1,3-dioxa-5,7-diaza-azulene

Base Information

Chemical Name:(3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-4,5,8,8a-tetrahydro-3aH-1,3-dioxa-5,7-diaza-azulene
CAS No.:180302-25-4
Molecular Formula:C₂₃H₂₈N₂O₃
Molecular Weight:380.487
Hs Code.:

Synonyms:(3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-4,5,8,8a-tetrahydro-3aH-1,3-dioxa-5,7-diaza-azulene

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Chemical Property of (3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-4,5,8,8a-tetrahydro-3aH-1,3-dioxa-5,7-diaza-azulene

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Technology Process of (3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-4,5,8,8a-tetrahydro-3aH-1,3-dioxa-5,7-diaza-azulene

There total 2 articles about (3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-4,5,8,8a-tetrahydro-3aH-1,3-dioxa-5,7-diaza-azulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 170028-72-5
(3aS,4R,8R,8aS)-4,8-dibenzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-e][1,3]diazepin-6(7H)-one

: 333-27-7
methyl trifluoromethanesulfonate

: 180302-25-4
(3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-4,5,8,8a-tetrahydro-3aH-1,3-dioxa-5,7-diaza-azulene

Guidance literature:: In 1,2-dichloro-ethane; for 16h; Heating;
DOI:10.1021/jm970288b

Reference yield: 40.0%

: 1850-14-2
tetramethoxymethane

: 170870-15-2
(1R,1'R)-1,1'-((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(2-phenylethanamine)

: 180302-25-4
(3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-4,5,8,8a-tetrahydro-3aH-1,3-dioxa-5,7-diaza-azulene

Guidance literature:: With hexanoic acid; In toluene; Heating; continuous MeOH removal;
DOI:10.1016/S0040-4039(98)01263-5

Reference yield:

: 180302-25-4
(3aS,4R,8R,8aS)-4,8-Dibenzyl-6-methoxy-2,2-dimethyl-4,5,8,8a-tetrahydro-3aH-1,3-dioxa-5,7-diaza-azulene

: 1055036-64-0
3-[(3aS,4R,8R,8aS)-7-(3-Amino-benzyl)-4,8-dibenzyl-2,2-dimethyl-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-N-pyrazin-2-yl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 48 h

2: 54 percent / acetonitrile / 72 h / Heating

3: trimethylaluminum / 1,2-dichloro-ethane / 24 h / Heating

4: H₂ / 10percent Pd/C / CH₂Cl₂

With hydrogen; trimethylaluminum; sodium hydride; palladium on activated charcoal; In dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jm970288b