propargyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate

Base Information

• Chemical Name: propargyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate
• CAS No.: 945841-51-0
• Molecular Formula: C₉H₁₀O₅
• Molecular Weight: 198.175
• Mol file: 945841-51-0.mol

Synonyms:propargyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate

Chemical Property of propargyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Methyl-5-propargyloxycarbonyl-1,3-dioxane-2-one ≥98.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of propargyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate

There total 5 articles about propargyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.3%

prop-2-yn-1-yl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate (873849-85-5) + chloroformic acid ethyl ester (541-41-3) → propargyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate (945841-51-0)

Guidance literature:

prop-2-yn-1-yl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate; chloroformic acid ethyl ester; In tetrahydrofuran; for 1h; Sealed tube; Inert atmosphere; Cooling with ice;

With triethylamine; In tetrahydrofuran; at 25 ℃; Cooling with ice; Sealed tube; Inert atmosphere;

DOI:10.1039/c4ra07345b

Reference yield: 65.0%

pentafluorophenyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate (1252553-69-7) + propargyl alcohol (107-19-7) → propargyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate (945841-51-0) + 2,3,4,5,6-pentafluorophenol (771-61-9)

Guidance literature:

With cesium fluoride; In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield: 65.0%

pentafluorophenyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate (1252553-69-7) + propargyl alcohol (107-19-7) → propargyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate (945841-51-0)

Guidance literature:

With cesium fluoride; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1021/ja105332k

upstream raw materials:

5-methyl-2-oxo-[1,3]dioxane-5-carboxylic acid

propargyl alcohol

5-methyl-2-oxo-[1,3]dioxane-5-carboxylic acid chloride

pentafluorophenyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate