N-[3-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)propyl]sulfamide

Base Information

Chemical Name:N-[3-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)propyl]sulfamide
CAS No.:1204669-76-0
Molecular Formula:C₁₃H₁₃BrFN₇O₅S
Molecular Weight:478.259
Hs Code.:

Synonyms:N-[3-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)propyl]sulfamide

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Chemical Property of N-[3-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)propyl]sulfamide

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Technology Process of N-[3-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)propyl]sulfamide

There total 7 articles about N-[3-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)propyl]sulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 3-{4-[(3-aminopropyl)amino]-1,2,5-oxadiazol-3-yl}-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one hydroiodide

: 1204669-76-0
N-[3-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)propyl]sulfamide

Guidance literature:: With pyridine; SULFAMIDE; at 130 ℃; for 10h; Microwave irradiation;

Reference yield: 71.0%

: 1204669-75-9
3-{4-[(3-aminopropyl)amino]-1,2,5-oxadiazol-3-yl}-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one hydroiodide

: 1204669-76-0
N-[3-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)propyl]sulfamide

Guidance literature:: With pyridine; SULFAMIDE; at 130 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 914471-60-6
N-{4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}-2,2,2-trifluoroacetamide

: 1204669-76-0
N-[3-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)propyl]sulfamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.25 h / 0 °C

1.2: 72 h / 25 °C

1.3: 6 h / 50 °C

2.1: boron tribromide / dichloromethane / 2 h / -78 - 25 °C

2.2: 0 °C

3.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 25 °C

3.2: 2 h / 85 °C

4.1: chloro-trimethyl-silane; sodium iodide / methanol / 0.67 h / 25 °C

5.1: SULFAMIDE; pyridine / 10 h / 130 °C / Microwave irradiation

With pyridine; chloro-trimethyl-silane; di-isopropyl azodicarboxylate; boron tribromide; SULFAMIDE; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium iodide; In tetrahydrofuran; methanol; dichloromethane;