4-({3-[(aminosulfonyl)amino]propyl}amino)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Base Information

Chemical Name:4-({3-[(aminosulfonyl)amino]propyl}amino)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
CAS No.:1204669-39-5
Molecular Formula:C₁₂H₁₅BrFN₇O₄S
Molecular Weight:452.264
Hs Code.:

Synonyms:4-({3-[(aminosulfonyl)amino]propyl}amino)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

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Chemical Property of 4-({3-[(aminosulfonyl)amino]propyl}amino)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

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Technology Process of 4-({3-[(aminosulfonyl)amino]propyl}amino)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

There total 7 articles about 4-({3-[(aminosulfonyl)amino]propyl}amino)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1204669-76-0
N-[3-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)propyl]sulfamide

: 1204669-39-5
4-({3-[(aminosulfonyl)amino]propyl}amino)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Guidance literature:: With water; sodium hydroxide; In methanol; at 25 ℃; for 0.5h;

Reference yield: 42.0%

: 1204669-39-5
4-({3-[(Aminosulfonyl)amino]propyl}amino)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Guidance literature:

Reference yield:

: 1204669-71-5
4-(3-bromo-4-fluorophenyl)-3-{4-[(3-methoxypropyl)amino]-1,2,5-oxadiazol-3-yl}-1,2,4-oxadiazol-5(4H)-one

: 1204669-39-5
4-({3-[(aminosulfonyl)amino]propyl}amino)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 2 h / -78 - 25 °C

1.2: 0 °C

2.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 25 °C

2.2: 2 h / 85 °C

3.1: chloro-trimethyl-silane; sodium iodide / methanol / 0.67 h / 25 °C

4.1: SULFAMIDE; pyridine / 10 h / 130 °C / Microwave irradiation

5.1: water; sodium hydroxide / methanol / 0.5 h / 25 °C

With pyridine; chloro-trimethyl-silane; water; boron tribromide; SULFAMIDE; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium hydroxide; In methanol; dichloromethane;