7-Benzoylbenzofuran-5-ylacetic acid

Base Information

Chemical Name:7-Benzoylbenzofuran-5-ylacetic acid
CAS No.:97483-18-6
Molecular Formula:C₁₇H₁₂O₄
Molecular Weight:280.28
Hs Code.:
ChEMBL ID:CHEMBL78208
DSSTox Substance ID:DTXSID701300317

Synonyms:7-benzoylbenzofuran-5-ylacetic acid;CHEMBL78208;SCHEMBL10373531;DESJPZBHDAQZLB-UHFFFAOYSA-N;7-Benzoyl-5-benzofuranacetic acid;DTXSID701300317;97483-18-6

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Chemical Property of 7-Benzoylbenzofuran-5-ylacetic acid

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:280.07355886
Heavy Atom Count:21
Complexity:400

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(=O)C2=C3C(=CC(=C2)CC(=O)O)C=CO3

Technology Process of 7-Benzoylbenzofuran-5-ylacetic acid

There total 6 articles about 7-Benzoylbenzofuran-5-ylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 97483-15-3
(7-Benzoyl-2,3-dihydro-benzofuran-5-yl)-acetic acid

: 97483-18-6
7-benzoylbenzofuran-5-ylacetic acid

Guidance literature:: With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 2h; Heating;
DOI:10.1021/jm00161a030

Reference yield:

: 496-16-2
2.3-dihydrobenzofuran

: 97483-18-6
7-benzoylbenzofuran-5-ylacetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / AlCl₃ / CH₂Cl₂ / 0.5 h / -6 °C

2: 50.3 percent / sulfur, p-toluenesulfonic acid / 5 h / Heating

3: 70 percent / HOAc, H₂SO₄, H₂O / 4 h / Heating

4: 97 percent / conc. H₂SO₄ / toluene / 3 h / Heating

5: AlCl₃ / CS₂ / 2 h / Heating

6: aq. NaOH / methanol / 2 h / Heating

7: 56 percent / NBS, dibenzoyl peroxide / CCl₄ / 2 h / Heating

With sodium hydroxide; N-Bromosuccinimide; aluminium trichloride; sulfuric acid; water; toluene-4-sulfonic acid; sulfur; acetic acid; dibenzoyl peroxide; In methanol; carbon disulfide; tetrachloromethane; dichloromethane; toluene;
DOI:10.1021/jm00161a030

Reference yield:

: 69999-16-2
2,3-dihydrobenzofuran-5-acetic acid

: 97483-18-6
7-benzoylbenzofuran-5-ylacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / conc. H₂SO₄ / toluene / 3 h / Heating

2: AlCl₃ / CS₂ / 2 h / Heating

3: aq. NaOH / methanol / 2 h / Heating

4: 56 percent / NBS, dibenzoyl peroxide / CCl₄ / 2 h / Heating

With sodium hydroxide; N-Bromosuccinimide; aluminium trichloride; sulfuric acid; dibenzoyl peroxide; In methanol; carbon disulfide; tetrachloromethane; toluene;
DOI:10.1021/jm00161a030