1-{4-[5-((R)-2,2,4-Trimethyl-[1,3]dioxolan-4-yl)-thiazol-2-ylsulfanyl]-phenyl}-ethanone oxime

Base Information

Chemical Name:1-{4-[5-((R)-2,2,4-Trimethyl-[1,3]dioxolan-4-yl)-thiazol-2-ylsulfanyl]-phenyl}-ethanone oxime
CAS No.:171482-68-1
Molecular Formula:C₁₇H₂₀N₂O₃S₂
Molecular Weight:364.489
Hs Code.:

Synonyms:1-{4-[5-((R)-2,2,4-Trimethyl-[1,3]dioxolan-4-yl)-thiazol-2-ylsulfanyl]-phenyl}-ethanone oxime

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Chemical Property of 1-{4-[5-((R)-2,2,4-Trimethyl-[1,3]dioxolan-4-yl)-thiazol-2-ylsulfanyl]-phenyl}-ethanone oxime

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Technology Process of 1-{4-[5-((R)-2,2,4-Trimethyl-[1,3]dioxolan-4-yl)-thiazol-2-ylsulfanyl]-phenyl}-ethanone oxime

There total 4 articles about 1-{4-[5-((R)-2,2,4-Trimethyl-[1,3]dioxolan-4-yl)-thiazol-2-ylsulfanyl]-phenyl}-ethanone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 161387-24-2
4'-{5-[(4R)-2,2,4-trimethyl-1,3-dioxolan-4-yl]thiazol-2-ylthio}acetophenone

: 171482-68-1
1-{4-[5-((R)-2,2,4-Trimethyl-[1,3]dioxolan-4-yl)-thiazol-2-ylsulfanyl]-phenyl}-ethanone oxime

Guidance literature:: With hydroxylamine hydrochloride; sodium acetate; In ethanol; for 2h; Heating;
DOI:10.1021/jm00020a008

Reference yield:

: 159615-85-7
(R)-5-(1,2-dihydroxyprop-2-yl)-2-(methylthio)thiazole

: 171482-68-1
1-{4-[5-((R)-2,2,4-Trimethyl-[1,3]dioxolan-4-yl)-thiazol-2-ylsulfanyl]-phenyl}-ethanone oxime

Guidance literature:: Multi-step reaction with 4 steps

1: PTSA / acetone / 0.75 h / Heating

2: NaSMe / dimethylformamide / 0.5 h / 130 °C

3: K₂CO₃ / dimethylformamide / 1.5 h / 130 °C

4: 90 percent / NH₂OH*HCl, NaOAc / ethanol / 2 h / Heating

With hydroxylamine hydrochloride; sodium acetate; potassium carbonate; toluene-4-sulfonic acid; sodium thiomethoxide; In ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00020a008

Reference yield:

: 161387-23-1
2-mercapto-5-[(4R)-2,2,4-trimethyl-1,3-dioxolan-4-yl]thiazole

: 171482-68-1
1-{4-[5-((R)-2,2,4-Trimethyl-[1,3]dioxolan-4-yl)-thiazol-2-ylsulfanyl]-phenyl}-ethanone oxime

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 1.5 h / 130 °C

2: 90 percent / NH₂OH*HCl, NaOAc / ethanol / 2 h / Heating

With hydroxylamine hydrochloride; sodium acetate; potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00020a008