(1S,3S,4R)-p-menth-3-yl (S)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate

Base Information

• Chemical Name: (1S,3S,4R)-p-menth-3-yl (S)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate
• CAS No.: 118166-32-8
• Molecular Formula: C₁₉H₂₄Cl₂O₃
• Molecular Weight: 371.304
• Mol file: 118166-32-8.mol

Synonyms:(1S,3S,4R)-p-menth-3-yl (S)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate

Chemical Property of (1S,3S,4R)-p-menth-3-yl (S)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S,3S,4R)-p-menth-3-yl (S)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate

There total 2 articles about (1S,3S,4R)-p-menth-3-yl (S)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

(1S,2R,5S)-(+)-menthol (15356-60-2) + 6,7-dichloro-2,3-dihydro-2-benzofurancarboxylic acid (62717-17-3) → (1S,3S,4R)-p-menth-3-yl (S)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate (118166-32-8) + (1S,3S,4R)-p-menth-3-yl (R)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate (118166-31-7,118166-32-8,118166-33-9,124475-19-0)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 6.5h; Heating;

Reference yield: 39.0%

(1S,2R,5S)-(+)-menthol (15356-60-2) + 6,7-dichloro-2,3-dihydro-2-benzofurancarboxylic acid (62717-17-3) → (1S,3S,4R)-p-menth-3-yl (S)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate (118166-32-8) + (1S,3S,4R)-p-menth-3-yl (R)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate (118166-31-7,118166-32-8,118166-33-9,124475-19-0)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 6.5h; Heating;

Reference yield: 97.0%

(1S,3S,4R)-p-menth-3-yl (S)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate (118166-32-8) → (1S,2R,5S)-(+)-menthol (15356-60-2) + (S)-6,7-Dichloro-2,3-dihydro-benzofuran-2-carboxylic acid (118206-01-2)

Guidance literature:

With sodium hydroxide; In acetonitrile; for 17h; Ambient temperature;

upstream raw materials:

(1S,2R,5S)-(+)-menthol

6,7-dichloro-2,3-dihydro-2-benzofurancarboxylic acid

Downstream raw materials:

(1S,2R,5S)-(+)-menthol

methyl (S)-6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylate

(S)-6,7-Dichloro-2,3-dihydro-benzofuran-2-carboxylic acid

(S)-6,7-dichloro-5-(N,N-dimethylsulfamoyl)-2,3-dihydrobenzofuran-2-carboxylic acid