62717-17-3

Basic information

• Product Name: 6,7-Dichloro-2,3-dihydrobenzofuran-2-carboxylic acid
• Synonyms: 6,7-Dichloro-2,3-dihydrobenzofuran-2-carboxylic acid;6,7-dichloro-2,3-dihydro-2-benzofurancarboxylic acid
• CAS NO: 62717-17-3
• Molecular Formula: C₉H₆Cl₂O₃
• Molecular Weight: 233.04814
• Mol File: 62717-17-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6,7-Dichloro-2,3-dihydrobenzofuran-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Dichloro-2,3-dihydrobenzofuran-2-carboxylic acid(62717-17-3)
• EPA Substance Registry System: 6,7-Dichloro-2,3-dihydrobenzofuran-2-carboxylic acid(62717-17-3)

Safety Data

• Hazardous Substances Data: 62717-17-3(Hazardous Substances Data)

Upstream product

• 62717-14-0 2,3-dichloro-6-propenylphenol 
• 62717-15-1 2,3-dichloro-6-(2,3-epoxypropyl)phenol 
• 68279-46-9 2,3-dichloro-1-(propenyloxy)benzene 
• 576-24-9 2,3-dichlorophenol 
• 62717-16-2 6,7-dichloro-2,3-dihydro-2-hydroxymethylbenzofuran 

Downstream Products

• 62717-22-0 6,7-Dichloro-2,3-dihydro-5(4-methoxybenzoyl)benzofuran-2-carboxylic acid 
• 62717-23-1 6,7-dichloro-2,3-dihydro-5-(phenylacetyl)-2-benzofurancarboxylic acid 
• 90246-52-9 6,7-dichloro-2,3-dihydro-5-benzoylbenzofuran-2-carboxylic acid 
• 43119-53-5 ethyl 2,3-dihydro-1-benzofuran-2-carboxylate 
• 118196-05-7 (R)-3-((R)-6,7-Dichloro-2,3-dihydro-benzofuran-2-carbonyl)-4-phenyl-oxazolidin-2-one 
• 118166-27-1 (R)-3-((S)-6,7-Dichloro-2,3-dihydro-benzofuran-2-carbonyl)-4-phenyl-oxazolidin-2-one 
• 108940-99-4 (S)-6,7-dichloro-5-(N,N-dimethylsulfamoyl)-2,3-dihydrobenzofuran-2-carboxylic acid 
• 108940-98-3 (R)-6,7-dichloro-5-(N,N-dimethylsulfamoyl)-2,3-dihydrobenzofuran-2-carboxylic acid 
• 118166-33-9 (1R,3R,4S)-p-menth-3-yl (S)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate 
• 118166-31-7 (1R,3R,4S)-p-menth-3-yl (R)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate 
• 118166-32-8 (1S,3S,4R)-p-menth-3-yl (S)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate 
• 118166-31-7 (1S,3S,4R)-p-menth-3-yl (R)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate 

Relevant articles and documents

α-Adrenoreceptor Reagents. 2. Effects of Modification of the 1,4-Benzodioxan Ring System on α-Adrenoreceptor Activity

Modification of the 1,4-benzodioxan ring present in RX 781094 (1) has not previously been considered.This paper describes a number of analogues of this ring system, including compounds in which one of the oxygen atoms has been replaced by a methylene group and also those in which the ring size has been changed to give, for example, furan and thiophene derivatives.The dihydroxybenzofuranylimidazoline compound 7 is the only analogue possesing presynaptic antagonist potency and selectivity comparable to that of 1.In view of this result, a number of derivatives was prepared to determine the structure-activity relationships within this series.Many derivatives, as well as the parent compound 7, were found to possess presynaptic α2-adrenoreceptor antagonist and postsynaptic α1-adrenoreceptor partial agonist properties.Two of the selective presynaptic antagonists,13 and 14, possess greater potency and selectivity than that possessed by 1.The 5-chloro derivative 25 is twice as potent as 1 after oral administration but only about half as potent when given intravenously.

(Acylaryloxy)acetic Acid Diuretics. 3. 2,3-Dihydro-5-acyl-2-benzofurancarboxylic Acids, a New Class of Uricosuric Diuretics

The discovery that dihydroethacrynic acid and other (4-acylphenoxy)acetic acids possessed modest but significant uricosuric and diuretic activity prompted our investigation of the related 2,3-dihydro-5-acyl-2-benzofurancarboxylic acids.Synthetic routes to

2,3-Dihydro-6,7-disubstituted-5-acyl benzofuran-2-carboxylic acids

2,3-Dihydro-6,7-disubstituted-5-(acyl)benzofuran-2-carboxylic acids, the pharmaceutically acceptable salt, ester and amide derivatives thereof and combinations of these compounds with antikaluretic agents are disclosed having diuretic-saluretic, uricosuri

6,7-Disubstituted-5-(acyl)benzofuran-2-carboxylic acids

6,7-Disubstituted-5-(acyl)benzofuran-2-carboxylic acids, the pharmaceutically acceptable salt, ester and amide derivatives thereof and combinations of these compounds with antikaluretic agents are disclosed having diuretic-saluretic, uricosuric and antihy

5-(Hydroxy (substituted) methyl)-2,3-dihydrobenzo furan-2-carboxylic acid and its derivatives

5-[Hydroxy(substituted)methyl]-2,3-dihydrobenzo-furan-2-carboxylic acids, the pharmaceutically acceptable salt, ester and amide derivatives thereof and combinations of these compounds with antikaluretic agents are disclosed having diuretic-saluretic, uricosuric and antihypertensive activity.