5-(4-(2-N-trifluoroacetylaminoethyl)-1-piperazinyl)-2'-nitroacetanilide

Base Information

• Chemical Name: 5-(4-(2-N-trifluoroacetylaminoethyl)-1-piperazinyl)-2'-nitroacetanilide
• CAS No.: 1612254-21-3
• Molecular Formula: C₁₆H₂₀F₃N₅O₄
• Molecular Weight: 403.361

Synonyms:5-(4-(2-N-trifluoroacetylaminoethyl)-1-piperazinyl)-2'-nitroacetanilide

Chemical Property of 5-(4-(2-N-trifluoroacetylaminoethyl)-1-piperazinyl)-2'-nitroacetanilide

Chemical Property:

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Technology Process of 5-(4-(2-N-trifluoroacetylaminoethyl)-1-piperazinyl)-2'-nitroacetanilide

There total 1 articles about 5-(4-(2-N-trifluoroacetylaminoethyl)-1-piperazinyl)-2'-nitroacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,2,2-trifluoro-N-(2-(piperazin-1-yl)ethyl)acetamide (87980-84-5) + N-(5-chloro-2-nitrophenyl)acetamide (5443-33-4) → 5-(4-(2-N-trifluoroacetylaminoethyl)-1-piperazinyl)-2'-nitroacetanilide (1612254-21-3)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 120 ℃;

DOI:10.1021/jm5003028

Reference yield: 94.0%

5-(4-(2-N-trifluoroacetylaminoethyl)-1-piperazinyl)-2'-nitroacetanilide (1612254-21-3) → 5-(4-(2-N-trifluoroacetylaminoethyl)-1-piperazinyl)-2-nitroaniline (1612254-29-1)

Guidance literature:

With sulfuric acid; at 80 ℃;

DOI:10.1021/jm5003028

Reference yield:

5-(4-(2-N-trifluoroacetylaminoethyl)-1-piperazinyl)-2'-nitroacetanilide (1612254-21-3) → C14H20F3N5O (1612254-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 80 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 20 °C / 2068.65 Torr

With sulfuric acid; palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate;

DOI:10.1021/jm5003028

upstream raw materials:

2,2,2-trifluoro-N-(2-(piperazin-1-yl)ethyl)acetamide

N-(5-chloro-2-nitrophenyl)acetamide

Downstream raw materials:

5-(4-(2-N-trifluoroacetylaminoethyl)-1-piperazinyl)-2-nitroaniline

C₁₄H₂₀F₃N₅O

5-(4-(2-N-trifluoroacetylaminoethylpiperazin-1-yl))-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole

5-(4-(2-N-trifluoroacetyl)aminoethylpiperazin-1-yl)-2-[2′-(4-ethoxyphenyl)-5′-benzimidazolyl]benzimidazole

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