methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxy-3-phenylpropanoate

Base Information

Chemical Name:methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxy-3-phenylpropanoate
CAS No.:131066-60-9
Molecular Formula:C₂₆H₃₅N₂O₈P
Molecular Weight:534.546
Hs Code.:

Synonyms:methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxy-3-phenylpropanoate

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Chemical Property of methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxy-3-phenylpropanoate

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Technology Process of methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxy-3-phenylpropanoate

There total 5 articles about methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxy-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2018-66-8
Z-Leu-OH

: 131066-60-9
methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxy-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / N-hydroxybenzotriazole (HOBT), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide (EDC) / CH₂Cl₂ / Ambient temperature

2: H₂ / 5percent Pd/C / ethyl acetate / 5 h

3: Et₃N, 4-A molecular sieves / CH₂Cl₂ / 48 h

With 4 A molecular sieve; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ja00001a043

Reference yield:

: 131066-56-3
methyl O--(S)-2-hydroxy-3-phenylpropanoate

: 131066-60-9
methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxy-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/C / ethyl acetate / 5 h

2: Et₃N, 4-A molecular sieves / CH₂Cl₂ / 48 h

With 4 A molecular sieve; hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ja00001a043

Reference yield:

: 13673-95-5
(S)-methyl 2-hydroxy-3-phenylpropanoate

: 131066-60-9
methyl O-<<<(carbobenzoxyamino)methyl>methoxyphosphinyl>-L-leucyl>-(S)-2-hydroxy-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / N-hydroxybenzotriazole (HOBT), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide (EDC) / CH₂Cl₂ / Ambient temperature

2: H₂ / 5percent Pd/C / ethyl acetate / 5 h

3: Et₃N, 4-A molecular sieves / CH₂Cl₂ / 48 h

With 4 A molecular sieve; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ja00001a043