Technology Process of 2-chloro-5-pyridin-2-ylbenzamide
There total 5 articles about 2-chloro-5-pyridin-2-ylbenzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-chloro-5-pyridin-2-ylbenzoic acid;
With
isopropyl chloroformate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; toluene;
With
ammonia;
In
tetrahydrofuran; 1,4-dioxane; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: methanol / 45 h / 0 - 20 °C / Inert atmosphere
2.1: copper(l) iodide; potassium carbonate; triphenylphosphine; palladium diacetate / tetrahydrofuran / 65 °C / Inert atmosphere
3.1: potassium hydroxide / methanol / 60 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine; isopropyl chloroformate / tetrahydrofuran; toluene / Inert atmosphere
4.2: Inert atmosphere
With
copper(l) iodide; palladium diacetate; potassium carbonate; isopropyl chloroformate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide;
In
tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm500610n
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(l) iodide; potassium carbonate; triphenylphosphine; palladium diacetate / tetrahydrofuran / 65 °C / Inert atmosphere
2.1: potassium hydroxide / methanol / 60 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine; isopropyl chloroformate / tetrahydrofuran; toluene / Inert atmosphere
3.2: Inert atmosphere
With
copper(l) iodide; palladium diacetate; potassium carbonate; isopropyl chloroformate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide;
In
tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm500610n
