2-chloro-N-(6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)-5-(pyridin-2-yl)benzamide

Base Information

Chemical Name:2-chloro-N-(6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)-5-(pyridin-2-yl)benzamide
CAS No.:1143020-84-1
Molecular Formula:C₂₈H₂₉ClN₆O₄S₂
Molecular Weight:613.161
Hs Code.:

Synonyms:2-chloro-N-(6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)-5-(pyridin-2-yl)benzamide

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Chemical Property of 2-chloro-N-(6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)-5-(pyridin-2-yl)benzamide

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Technology Process of 2-chloro-N-(6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)-5-(pyridin-2-yl)benzamide

There total 9 articles about 2-chloro-N-(6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)-5-(pyridin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 109-01-3
1-methyl-piperazine

: 79-37-8
oxalyl dichloride

: 1143019-66-2
2-chloro-5-pyridin-2-ylbenzamide

: 1143020-47-6
6-(3-iodopropylsulfonyl)benzothiazol-2-amine

: 1143020-84-1
2-chloro-N-(6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)-5-(pyridin-2-yl)benzamide

Guidance literature:: oxalyl dichloride; 2-chloro-5-pyridin-2-ylbenzamide; In tetrahydrofuran; at 120 ℃; for 0.0833333h;

6-(3-iodopropylsulfonyl)benzothiazol-2-amine; In tetrahydrofuran; at 120 ℃; for 0.0833333h;

1-methyl-piperazine; In tetrahydrofuran; for 16h;

Reference yield:

: 19094-56-5
2-chloro-5-iodobenzoic acid

: 1143020-84-1
2-chloro-N-(6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)-5-(pyridin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanol / 45 h / 0 - 20 °C / Inert atmosphere

2.1: copper(l) iodide; potassium carbonate; triphenylphosphine; palladium diacetate / tetrahydrofuran / 65 °C / Inert atmosphere

3.1: potassium hydroxide / methanol / 60 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; isopropyl chloroformate / tetrahydrofuran; toluene / Inert atmosphere

4.2: Inert atmosphere

5.1: tetrahydrofuran / 0.08 h / 120 °C / Microwave irradiation

6.1: tetrahydrofuran / 0.08 h / 120 °C / Microwave irradiation

7.1: tetrahydrofuran / 16 h / 20 °C

With copper(l) iodide; palladium diacetate; potassium carbonate; isopropyl chloroformate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm500610n

Reference yield:

: 1432795-28-2,662138-96-7
2-pyridineboronic acid N-phenyldiethanolamine ester

: 1143020-84-1
2-chloro-N-(6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)-5-(pyridin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(l) iodide; potassium carbonate; triphenylphosphine; palladium diacetate / tetrahydrofuran / 65 °C / Inert atmosphere

2.1: potassium hydroxide / methanol / 60 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; isopropyl chloroformate / tetrahydrofuran; toluene / Inert atmosphere

3.2: Inert atmosphere

4.1: tetrahydrofuran / 0.08 h / 120 °C / Microwave irradiation

5.1: tetrahydrofuran / 0.08 h / 120 °C / Microwave irradiation

6.1: tetrahydrofuran / 16 h / 20 °C

With copper(l) iodide; palladium diacetate; potassium carbonate; isopropyl chloroformate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm500610n