BOC-ASP(OTBU)-OSU

Base Information

• Chemical Name: BOC-ASP(OTBU)-OSU
• CAS No.: 50715-50-9
• Molecular Formula: C17H26N2O8
• Molecular Weight: 386.402
• Mol file: 50715-50-9.mol

Synonyms:Butanoicacid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxo-,1,1-dimethylethyl ester, (3S)- (9CI);Butanoic acid,3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxo-,1,1-dimethylethyl ester, (S)-;(2,5-dioxopyrrolidin-1-yl) tert-butyl (2S)-2-(tert-butoxycarbonylamino)butanedioate;Boc-Asp(OtBu)-O-(NHS);Boc-Asp(OtBu)-OSu;Boc-L-aspartic acid 4-(tert-butyl) 1-(hydroxysuccinimide) ester;Boc-L-aspartic acid 4-(tert-butyl) 1-(hydroxysuccinimide) ester;

Chemical Property of BOC-ASP(OTBU)-OSU

Chemical Property:

• Melting Point: 98-102 °C
• Refractive Index: 1.508
• PKA: 10.23±0.46(Predicted)
• PSA: 128.31000
• Density: 1.25g/cm3
• LogP: 1.54750
• Storage Temp.: −20°C
• Sensitive.: Moisture Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

BOC-Asp(OTBu)-OSU ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-ASP(OTBU)-OSU

There total 2 articles about BOC-ASP(OTBU)-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ O1-(2,5-dioxopyrrolidin-1-yl)-O4-tert-butyl-(2S)-2-(tert-butoxycarbonylamino)-butanedioate (50715-50-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; at 0 - 20 ℃;

Reference yield: 93.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Boc-Asp(OtBu)-OH (1676-90-0) → O1-(2,5-dioxopyrrolidin-1-yl)-O4-tert-butyl-(2S)-2-(tert-butoxycarbonylamino)-butanedioate (50715-50-9)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 21h;

DOI:10.1039/c6ob02191c

Reference yield: 100.0%

(rac)-mexiletine hydrochloride (5370-01-4) + O1-(2,5-dioxopyrrolidin-1-yl)-O4-tert-butyl-(2S)-2-(tert-butoxycarbonylamino)-butanedioate (50715-50-9) → N-Boc-(S)-aspartic acid (tert-butyl ester)mexiletine

Guidance literature:

With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

Boc-Asp(OtBu)-OH

Downstream raw materials:

C₄₁H₇₃N₅O₂₀

(3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid tert-butyl ester

N-(3-{3,5-bis-[3-(3-tert-butoxycarbonyl-2-tert-butoxycarbonylamino-propionylamino)-propyl]-phenyl}-propyl)-3-tert-butoxycarbonylamino-succinamic acid tert-butyl ester

tert-butyl 3(S)-(tert-butoxycarbonylamino)-4-(p-tolylsulfonyloxy)butanoate

Refernces

• 1、 Husak, Antonija,Noichl, Benjamin P.,?umanovac Ramljak, Tatjana,Sohora, Margareta,?kalamera,Budi?a, Nediljko,Basari?, Nikola. "Photochemical formation of quinone methides from peptides containing modified tyrosine". supporting information. p. 10894 - 10905. Retrieved 2016/12/06.
• 2、 -. "BETA-SUBSTITUTED BETA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS". Paragraph 0551; 0620. . Retrieved 2015/09/22.