8-Chloro-7-fluoro-2-(4-fluoro-phenyl)-3,4-dihydro-2H-benzo[1,4]thiazine

Base Information

Chemical Name:8-Chloro-7-fluoro-2-(4-fluoro-phenyl)-3,4-dihydro-2H-benzo[1,4]thiazine
CAS No.:151295-19-1
Molecular Formula:C₁₄H₁₀ClF₂NS
Molecular Weight:297.756
Hs Code.:

Synonyms:8-Chloro-7-fluoro-2-(4-fluoro-phenyl)-3,4-dihydro-2H-benzo[1,4]thiazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-Chloro-7-fluoro-2-(4-fluoro-phenyl)-3,4-dihydro-2H-benzo[1,4]thiazine

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Technology Process of 8-Chloro-7-fluoro-2-(4-fluoro-phenyl)-3,4-dihydro-2H-benzo[1,4]thiazine

There total 5 articles about 8-Chloro-7-fluoro-2-(4-fluoro-phenyl)-3,4-dihydro-2H-benzo[1,4]thiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 151295-16-8
8-Chloro-7-fluoro-2-(4-fluoro-phenyl)-4H-benzo[1,4]thiazin-3-one

: 151295-19-1
8-Chloro-7-fluoro-2-(4-fluoro-phenyl)-3,4-dihydro-2H-benzo[1,4]thiazine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.5h; Ambient temperature;
DOI:10.1021/jm00074a028

Reference yield:

: 29270-33-5
2-bromo-2-(4-fluorophenyl)acetic acid

: 151295-19-1
8-Chloro-7-fluoro-2-(4-fluoro-phenyl)-3,4-dihydro-2H-benzo[1,4]thiazine

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / 1.) NaOH / H₂O; ethanol / 2 h / Heating

2: 36 percent / FeSO₄*7H₂O, NH₄OH / H₂O / 1.) 2 h, RT, 2.) 15 min, 50 deg C

3: 36 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

With ammonium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; iron(II) sulfate; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm00074a028

Reference yield:

: 2-chloro-3-fluoro-6-nitrobenzene-1-thiol

: 151295-19-1
8-Chloro-7-fluoro-2-(4-fluoro-phenyl)-3,4-dihydro-2H-benzo[1,4]thiazine

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / 1.) NaOH / H₂O; ethanol / 2 h / Heating

2: 36 percent / FeSO₄*7H₂O, NH₄OH / H₂O / 1.) 2 h, RT, 2.) 15 min, 50 deg C

3: 36 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

With ammonium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; iron(II) sulfate; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm00074a028