4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-2-methyl-phenol

Base Information

Chemical Name:4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-2-methyl-phenol
CAS No.:98088-87-0
Molecular Formula:C₂₈H₃₁FN₄O
Molecular Weight:458.579
Hs Code.:

Synonyms:4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-2-methyl-phenol

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Chemical Property of 4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-2-methyl-phenol

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Technology Process of 4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-2-methyl-phenol

There total 4 articles about 4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-2-methyl-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75970-64-8
1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amine dihydrobromide

: 98088-87-0
4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-2-methyl-phenol

Guidance literature:: With sodium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 90 ℃;
DOI:10.1021/jm00150a029

Reference yield:

: 73734-07-3
(1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine

: 98088-87-0
4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-2-methyl-phenol

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

3: Na₂CO₃, KI / dimethylformamide / 90 °C

With hydrogen bromide; sodium carbonate; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029

Reference yield:

: 84501-68-8
ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate

: 98088-87-0
4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-2-methyl-phenol

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

2: Na₂CO₃, KI / dimethylformamide / 90 °C

With hydrogen bromide; sodium carbonate; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029