H-PHG-NH2 HCL

Base Information

• Chemical Name: H-PHG-NH2 HCL
• CAS No.: 60079-51-8
• Molecular Formula: C8H10 N2 O . Cl H
• Molecular Weight: 186.641
• Hs Code.: 2924299090
• Mol file: 60079-51-8.mol

Synonyms:Benzeneacetamide,a-amino-, monohydrochloride, (S)-;Benzeneacetamide, a-amino-, monohydrochloride, (aS)- (9CI);(2S)-2-Amino-2-phenylethanamide hydrochloride;(S)-2-Amino-2-phenylethanamide hydrochloride;L-2-Phenylglycinamidemonohydrochloride;

Chemical Property of H-PHG-NH2 HCL

Chemical Property:

• PSA: 69.11000
• LogP: 2.37430
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

H-L-Phg-NH2*HCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-PHG-NH2 HCL

There total 4 articles about H-PHG-NH2 HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid (2900-27-8) → (S)-phenylglycinamide hydrochloride (60079-51-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HOBt; EDC / dimethylformamide / 0.25 h / 0 °C

1.2: ammonium hydroxide / dimethylformamide

2.1: 4 N HCl / dioxane

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/jm020209i

Reference yield:

(RS)-phenylglycinamide hydrochloride (51703-58-3) → (R)-phenylglycine amide hydrochloride (63291-39-4) + (S)-phenylglycinamide hydrochloride (60079-51-8)

Guidance literature:

With chiral stationary phase including isopropyl-functionalized CF₆; In methanol; acetic acid; triethylamine; acetonitrile; at 20 ℃; Purification / work up;

Reference yield:

Boc-L-Phg-NH2 (143978-92-1) → (S)-phenylglycinamide hydrochloride (60079-51-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1021/jm020209i

upstream raw materials:

Boc-L-Phg-NH₂

(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

(RS)-phenylglycinamide hydrochloride

Downstream raw materials:

(S)-2-phenyl-2-(3-(4-(pyridin-4-yl)thiazol-2-yl)ureido)acetamide

L-phenylglycine amide

{(1S,2S,4R)-1-Benzyl-4-[((S)-carbamoyl-phenyl-methyl)-carbamoyl]-2-hydroxy-5-phenyl-pentyl}-carbamic acid tert-butyl ester

Refernces

• 1、 Ward, Yancey D.,Thomson, David S.,Frye, Leah L.,Cywin, Charles L.,Morwick, Tina,Emmanuel, Michel J.,Zindell, Renée,McNeil, Daniel,Bekkali, Younes,Giradot, Marc,Hrapchak, Matt,DeTuri, Molly,Crane, Kathy,White, Della,Pav, Susan,Wang, Yong,Hao, Ming-Hong,Grygon, Christine A.,Labadia, Mark E.,Freeman, Dorothy M.,Davidson, Walter,Hopkins, Jerry L.,Brown, Maryanne L.,Spero, Denice M.. "Design and synthesis of dipeptide nitriles as reversible and potent cathepsin S inhibitors". . p. 5471 - 5482. Retrieved 2007/10/03.