benzyl (3R,4R)-3-((cyclopropylamino)methyl)-4-fluoropyrrolidine-1-carboxylate hydrochloride

Base Information

Chemical Name:benzyl (3R,4R)-3-((cyclopropylamino)methyl)-4-fluoropyrrolidine-1-carboxylate hydrochloride
CAS No.:1314595-21-5
Molecular Formula:C₁₆H₂₁FN₂O₂*ClH
Molecular Weight:328.814
Hs Code.:

Synonyms:benzyl (3R,4R)-3-((cyclopropylamino)methyl)-4-fluoropyrrolidine-1-carboxylate hydrochloride

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Chemical Property of benzyl (3R,4R)-3-((cyclopropylamino)methyl)-4-fluoropyrrolidine-1-carboxylate hydrochloride

Chemical Property:

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Technology Process of benzyl (3R,4R)-3-((cyclopropylamino)methyl)-4-fluoropyrrolidine-1-carboxylate hydrochloride

There total 2 articles about benzyl (3R,4R)-3-((cyclopropylamino)methyl)-4-fluoropyrrolidine-1-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 949495-20-9
benzyl (3R,4S)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate

: 1314595-21-5
benzyl (3R,4R)-3-((cyclopropylamino)methyl)-4-fluoropyrrolidine-1-carboxylate hydrochloride

Guidance literature:: benzyl (3R,4S)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate; With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In acetonitrile; at -27 - 25 ℃; for 48h;

With sodium hydroxide; In water; acetonitrile; at 18 ℃; pH=9.5;

With hydrogenchloride; In methanol; di-isopropyl ether; ethyl acetate; at 20 ℃;

Reference yield:

: 949495-21-0
benzyl (3R,4S)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate hydrochloride

: 1314595-21-5
benzyl (3R,4R)-3-((cyclopropylamino)methyl)-4-fluoropyrrolidine-1-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / Cooling with ice

2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / acetonitrile / 48 h / -27 - 25 °C

2.2: 18 °C / pH 9.5

2.3: 20 °C

With sodium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In water; acetonitrile;