4-{[(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid methyl ester

Base Information

• Chemical Name: 4-{[(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid methyl ester
• CAS No.: 1345866-84-3
• Molecular Formula: C₃₂H₃₂Cl₂FN₃O₅
• Molecular Weight: 628.528

Synonyms:4-{[(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid methyl ester

Chemical Property of 4-{[(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid methyl ester

Chemical Property:

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Technology Process of 4-{[(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid methyl ester

There total 20 articles about 4-{[(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloro-3-[1-(3-chloro-2-fluorophenyl)-meth-(E)-ylidene]-1,3-dihydroindol-2-one (908027-64-5) + 4-{2-[3,3-dimethyl-but-(E)-ylideneamino]acetylamino}-3-methoxybenzoic acid methyl ester (1345866-83-2) → 4-{[(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid methyl ester (1345866-84-3) + 4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid methyl ester (1419186-30-3) + 4-{[(2'S,3'S,4'S,5'S)-6-chloro-4'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-2'-carbonyl]amino}-3-methoxybenzoic acid methyl ester

Guidance literature:

With C₅₂H₄₄F₁₂FeO₂P₂; silver(I) acetate; triethylamine; In toluene; at 20 ℃; for 48h; Reagent/catalyst;

DOI:10.1021/op3003213

Reference yield:

6-chloro-3-[1-(3-chloro-2-fluorophenyl)-meth-(E)-ylidene]-1,3-dihydroindol-2-one (908027-64-5) + 4-{2-[3,3-dimethyl-but-(E)-ylideneamino]acetylamino}-3-methoxybenzoic acid methyl ester (1345866-83-2) → 4-{[(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid methyl ester (1345866-84-3) + 4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid methyl ester (1419186-30-3) + 4-{[(2'S,3'S,4'S,5'S)-6-chloro-4'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-2'-carbonyl]amino}-3-methoxybenzoic acid methyl ester + 4-{[(2'S,3'S,4'S,5'S)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid methyl ester

Guidance literature:

With (C₅H₅)Fe(C₅H₃(CH(CH₃)P(C₆H₃(CF₃)2)2)P(C₆H₁₁)2); silver(I) acetate; triethylamine; In toluene; at 20 ℃; for 48h; Reagent/catalyst;

DOI:10.1021/op3003213

Reference yield:

6-chloro-3-[1-(3-chloro-2-fluorophenyl)-meth-(E)-ylidene]-1,3-dihydroindol-2-one (908027-64-5) + 4-{2-[3,3-dimethyl-but-(E)-ylideneamino]acetylamino}-3-methoxybenzoic acid methyl ester (1345866-83-2) → 4-{[(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid methyl ester (1345866-84-3) + 4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid methyl ester (1419186-30-3) + 4-{[(2'S,3'S,4'S,5'S)-6-chloro-4'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-2'-carbonyl]amino}-3-methoxybenzoic acid methyl ester + 4-{[(2'S,3'S,4'S,5'S)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid methyl ester + 4-{[(2'R,3'R,4'S,5'S)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid methyl ester

Guidance literature:

With silver(I) acetate; triethylamine; (R,S)-(±)-1-(2-diphenylphosphino-1-naphthyl)isoquinoline; In toluene; at 20 ℃; for 48h; Reagent/catalyst;

DOI:10.1021/op3003213

upstream raw materials:

6-chloro-2-oxindole

2-fluoro-3-chlorobenzaldehyde

methyl 3-methoxy-4-aminobenzoate

6-chloro-3-[1-(3-chloro-2-fluorophenyl)-meth-(E)-ylidene]-1,3-dihydroindol-2-one

Downstream raw materials:

4-{[(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidin]e-5'-carbonyl]-amino}-3-methoxy-benzoic acid

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