(R)-7-cyano-18-(2,4-difluorophenyl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyciopenta[h][1,6,10,12]oxatriazacycloheptadecine

Base Information

Chemical Name:(R)-7-cyano-18-(2,4-difluorophenyl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyciopenta[h][1,6,10,12]oxatriazacycloheptadecine
CAS No.:1356007-22-1
Molecular Formula:C₂₄H₂₃FN₆O
Molecular Weight:430.485
Hs Code.:

Synonyms:(R)-7-cyano-18-(2,4-difluorophenyl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyciopenta[h][1,6,10,12]oxatriazacycloheptadecine

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Chemical Property of (R)-7-cyano-18-(2,4-difluorophenyl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyciopenta[h][1,6,10,12]oxatriazacycloheptadecine

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Technology Process of (R)-7-cyano-18-(2,4-difluorophenyl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyciopenta[h][1,6,10,12]oxatriazacycloheptadecine

There total 12 articles about (R)-7-cyano-18-(2,4-difluorophenyl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyciopenta[h][1,6,10,12]oxatriazacycloheptadecine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.2%

: 1356010-38-2
4-amino-2-(2-(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-ylamino)ethylamino)ethoxy)benzonitrile

: 1356007-22-1
(R)-7-cyano-18-(2,4-difluorophenyl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyciopenta[h][1,6,10,12]oxatriazacycloheptadecine

: 1356007-24-3
(S)-7-cyano-18-(2,4-difluorophenyl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyciopenta[h][1,6,10,12]oxatriazacycloheptadecine

Guidance literature:: 4-amino-2-(2-(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-ylamino)ethylamino)ethoxy)benzonitrile; With sulfuric acid; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 18h; Cooling with ice;

In ethanol; hexane; Resolution of racemate;

Reference yield:

: 39835-14-8
2-hydroxy-4-nitro-benzonitrile

: 1356007-22-1
(R)-7-cyano-18-(2,4-difluorophenyl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyciopenta[h][1,6,10,12]oxatriazacycloheptadecine

: 1356007-24-3
(S)-7-cyano-18-(2,4-difluorophenyl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyciopenta[h][1,6,10,12]oxatriazacycloheptadecine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 18 h / 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: ammonium chloride; iron / water; methanol / 2 h / 65 °C

4.1: sulfuric acid / 1-methyl-pyrrolidin-2-one / 18 h / 100 °C / Cooling with ice

4.2: Chiral OD-H / Resolution of racemate

With sulfuric acid; iron; potassium carbonate; ammonium chloride; triethylamine; In 1-methyl-pyrrolidin-2-one; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 1356007-22-1
(R)-7-cyano-18-(2,4-difluorophenyl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyciopenta[h][1,6,10,12]oxatriazacycloheptadecine

: 1356007-24-3
(S)-7-cyano-18-(2,4-difluorophenyl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyciopenta[h][1,6,10,12]oxatriazacycloheptadecine

Guidance literature:: Multi-step reaction with 9 steps

1.1: diethyl ether; tetrahydrofuran / 2 h / 0 °C / Reflux

2.1: formic acid; dihydrogen peroxide / 20 - 50 °C

3.1: 3 h / 58 - 130 °C

4.1: ammonium hydroxide / 100 °C

5.1: trichlorophosphate; N,N-dimethyl-aniline / 110 °C

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

7.1: triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

8.1: ammonium chloride; iron / water; methanol / 2 h / 65 °C

9.1: sulfuric acid / 1-methyl-pyrrolidin-2-one / 18 h / 100 °C / Cooling with ice

9.2: Chiral OD-H / Resolution of racemate

With ammonium hydroxide; formic acid; sulfuric acid; dihydrogen peroxide; iron; ammonium chloride; N,N-dimethyl-aniline; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;