N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine hydrazide

Base Information

Chemical Name:N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine hydrazide
CAS No.:128718-60-5
Molecular Formula:C₃₇H₅₂N₈O₇S
Molecular Weight:752.935
Hs Code.:

Synonyms:N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine hydrazide

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Chemical Property of N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine hydrazide

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Technology Process of N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine hydrazide

There total 8 articles about N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 128632-71-3
N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine methyl ester

: 128718-60-5
N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine hydrazide

Guidance literature:: With hydrazine; In methanol; Ambient temperature;

Reference yield:

: 18942-49-9
Boc-D-Phe-OH

: 128718-60-5
N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCCI) / dimethylformamide / 4 °C

2: 76 percent / hydrazine / methanol / Ambient temperature

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; hydrazine; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 128718-60-5
N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine hydrazide

Guidance literature:: Multi-step reaction with 6 steps

1: 85.9 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), Et₃N / dimethylformamide / 4 °C

2: 83.6 percent / 6N HCl, dithioethane / ethyl acetate / 1 h

3: 89.7 percent / Et₃N / dimethylformamide / Ambient temperature

4: 3N HCl / ethyl acetate

5: Et₃N, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCCI) / dimethylformamide / 4 °C

6: 76 percent / hydrazine / methanol / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; ethane-1,2-dithiol; triethylamine; dicyclohexyl-carbodiimide; hydrazine; In methanol; ethyl acetate; N,N-dimethyl-formamide;