2',3-diazido-1-N-[(S)-4-azido-2-hydroxybutanoyl]-6'-(R)-methyl-paromamine

Base Information

• Chemical Name: 2',3-diazido-1-N-[(S)-4-azido-2-hydroxybutanoyl]-6'-(R)-methyl-paromamine
• CAS No.: 1236217-64-3
• Molecular Formula: C₁₇H₂₈N₁₀O₉
• Molecular Weight: 516.471
• Mol file: 1236217-64-3.mol

Synonyms:2',3-diazido-1-N-[(S)-4-azido-2-hydroxybutanoyl]-6'-(R)-methyl-paromamine

Chemical Property of 2',3-diazido-1-N-[(S)-4-azido-2-hydroxybutanoyl]-6'-(R)-methyl-paromamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',3-diazido-1-N-[(S)-4-azido-2-hydroxybutanoyl]-6'-(R)-methyl-paromamine

There total 1 articles about 2',3-diazido-1-N-[(S)-4-azido-2-hydroxybutanoyl]-6'-(R)-methyl-paromamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(S)-2-hydroxy-4-azidobutyric acid (959148-55-1) + 2',3-diazido-1-N-[(tert-butoxy)carbonyl]-6'-(R)-methyl-paromamine (1236217-62-1) → 2',3-diazido-1-N-[(S)-4-azido-2-hydroxybutanoyl]-6'-(R)-methyl-paromamine (1236217-64-3)

Guidance literature:

2',3-diazido-1-N-[(tert-butoxy)carbonyl]-6'-(R)-methyl-paromamine; With trifluoroacetic acid; In dichloromethane; for 1h;

(S)-2-hydroxy-4-azidobutyric acid; With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at -30 - 20 ℃; for 2h;

With methylamine; In ethanol; N,N-dimethyl-formamide; for 8h;

DOI:10.1016/j.bmc.2010.03.060

Reference yield: 70.0%

2',3-diazido-1-N-[(S)-4-azido-2-hydroxybutanoyl]-6'-(R)-methyl-paromamine (1236217-64-3) + acetic anhydride (108-24-7) → 3',4',6',6-tetra-O-acetyl-2',3-diazido-1-N-[(S)-4-azido-2-O-acetyl-butanoyl]-6'-(R)-methyl-paromamine (1375073-77-0)

Guidance literature:

With pyridine; at -12 ℃; for 16h;

DOI:10.1016/j.bmc.2010.03.060

Reference yield: 65.0%

2',3-diazido-1-N-[(S)-4-azido-2-hydroxybutanoyl]-6'-(R)-methyl-paromamine (1236217-64-3) → 2',3-diamino-1-N-[(S)-4-amino-2-hydroxybutanoyl]-6'-(R)-methyl-paromamine (1236217-56-3)

Guidance literature:

With water; sodium hydroxide; trimethylphosphane; In tetrahydrofuran; for 1h;

DOI:10.1016/j.bmc.2010.03.060

upstream raw materials:

(S)-2-hydroxy-4-azidobutyric acid

2',3-diazido-1-N-[(tert-butoxy)carbonyl]-6'-(R)-methyl-paromamine

Downstream raw materials:

2',3-diamino-1-N-[(S)-4-amino-2-hydroxybutanoyl]-6'-(R)-methyl-paromamine

3',4',6',6-tetra-O-acetyl-2',3-diazido-1-N-[(S)-4-azido-2-O-acetyl-butanoyl]-6'-(R)-methyl-paromamine