N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-chloro-5-nitropyrimidin-4-amine

Base Information

• Chemical Name: N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-chloro-5-nitropyrimidin-4-amine
• CAS No.: 1083302-80-0
• Molecular Formula: C₃₀H₃₁ClN₄O₃Si
• Molecular Weight: 559.14

Synonyms:N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-chloro-5-nitropyrimidin-4-amine

Chemical Property of N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-chloro-5-nitropyrimidin-4-amine

Chemical Property:

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Technology Process of N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-chloro-5-nitropyrimidin-4-amine

There total 2 articles about N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-chloro-5-nitropyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-amine (1018978-49-8) + 2,4-Dichloro-5-nitropyrimidine (49845-33-2) → N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-chloro-5-nitropyrimidin-4-amine (1083302-80-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.9b00533

Reference yield: 95.0%

→ N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-chloro-5-nitropyrimidin-4-amine (1083302-80-0)

Guidance literature:

Reference yield:

N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-chloro-5-nitropyrimidin-4-amine (1083302-80-0) → N4-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-chloropyrimidine-4,5-diamine (1415151-93-7)

Guidance literature:

With tin(II) chloride dihdyrate; In ethanol; at 80 ℃; for 3h; Sealed tube;

DOI:10.1021/acs.jmedchem.9b00533

upstream raw materials:

(1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-amine

2,4-Dichloro-5-nitropyrimidine

Downstream raw materials:

N⁴-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-chloropyrimidine-4,5-diamine

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