N-{(4-amino-2-(methylsulfonyl)furo[2,3-d]pyrimidin-5-yl)methyl}-4-nitro-N-phenylbenzenesulfonamide

Base Information

Chemical Name:N-{(4-amino-2-(methylsulfonyl)furo[2,3-d]pyrimidin-5-yl)methyl}-4-nitro-N-phenylbenzenesulfonamide
CAS No.:1383579-35-8
Molecular Formula:C₂₀H₁₇N₅O₇S₂
Molecular Weight:503.516
Hs Code.:

Synonyms:N-{(4-amino-2-(methylsulfonyl)furo[2,3-d]pyrimidin-5-yl)methyl}-4-nitro-N-phenylbenzenesulfonamide

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Chemical Property of N-{(4-amino-2-(methylsulfonyl)furo[2,3-d]pyrimidin-5-yl)methyl}-4-nitro-N-phenylbenzenesulfonamide

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Technology Process of N-{(4-amino-2-(methylsulfonyl)furo[2,3-d]pyrimidin-5-yl)methyl}-4-nitro-N-phenylbenzenesulfonamide

There total 6 articles about N-{(4-amino-2-(methylsulfonyl)furo[2,3-d]pyrimidin-5-yl)methyl}-4-nitro-N-phenylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1383579-47-2
N-({4-amino-2-(methylthio)furo[2,3-d]pyrimidin-5-yl}methyl)-4-nitro-N-phenylbenzenesulfonamide

: 1383579-35-8
N-{(4-amino-2-(methylsulfonyl)furo[2,3-d]pyrimidin-5-yl)methyl}-4-nitro-N-phenylbenzenesulfonamide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; at 0 - 20 ℃;
DOI:10.1055/s-0031-1290524

Reference yield:

: 62-53-3
aniline

: 1383579-35-8
N-{(4-amino-2-(methylsulfonyl)furo[2,3-d]pyrimidin-5-yl)methyl}-4-nitro-N-phenylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0 - 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 0 - 20 °C

With pyridine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; 2.1: Mitsunobu reaction / 2.2: Mitsunobu reaction;
DOI:10.1055/s-0031-1290524

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1383579-35-8
N-{(4-amino-2-(methylsulfonyl)furo[2,3-d]pyrimidin-5-yl)methyl}-4-nitro-N-phenylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0 - 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 0 - 20 °C

With pyridine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; 2.1: Mitsunobu reaction / 2.2: Mitsunobu reaction;
DOI:10.1055/s-0031-1290524