N-{1-[2,6-dichloro-4-(hydroxymethyl)benzoyl]-1H-pyrrolo[3,2-c]pyridin-4-yl}cyclopropanecarboxamide

Base Information

Chemical Name:N-{1-[2,6-dichloro-4-(hydroxymethyl)benzoyl]-1H-pyrrolo[3,2-c]pyridin-4-yl}cyclopropanecarboxamide
CAS No.:1415123-73-7
Molecular Formula:C₁₉H₁₅Cl₂N₃O₃
Molecular Weight:404.252
Hs Code.:

Synonyms:N-{1-[2,6-dichloro-4-(hydroxymethyl)benzoyl]-1H-pyrrolo[3,2-c]pyridin-4-yl}cyclopropanecarboxamide

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Chemical Property of N-{1-[2,6-dichloro-4-(hydroxymethyl)benzoyl]-1H-pyrrolo[3,2-c]pyridin-4-yl}cyclopropanecarboxamide

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Technology Process of N-{1-[2,6-dichloro-4-(hydroxymethyl)benzoyl]-1H-pyrrolo[3,2-c]pyridin-4-yl}cyclopropanecarboxamide

There total 5 articles about N-{1-[2,6-dichloro-4-(hydroxymethyl)benzoyl]-1H-pyrrolo[3,2-c]pyridin-4-yl}cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1415124-96-7
2,6-dichloro-4-(hydroxymethyl)benzoic acid

: 1415124-82-1
N-(1H-pyrrolo[3,2-c]pyridin-4-yl)cyclopropanecarboxamide

: 1415123-73-7
N-{1-[2,6-dichloro-4-(hydroxymethyl)benzoyl]-1H-pyrrolo[3,2-c]pyridin-4-yl}cyclopropanecarboxamide

Guidance literature:: 2,6-dichloro-4-(hydroxymethyl)benzoic acid; With dmap; 1-hydroxy-7-aza-benzotriazole; N,N-dimethyl-aniline; HATU;

N-(1H-pyrrolo[3,2-c]pyridin-4-yl)cyclopropanecarboxamide; With N-ethyl-N,N-diisopropylamine; at 20 ℃; for 15h;

Reference yield:

: 5372-81-6
dimethyl aminoterephthalate

: 1415123-73-7
N-{1-[2,6-dichloro-4-(hydroxymethyl)benzoyl]-1H-pyrrolo[3,2-c]pyridin-4-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuryl dichloride / diethyl ether / 15 h / 0 - 20 °C

2.1: sulfuric acid; sodium nitrite; acetic acid; phosphinic acid

3.1: sodium tetrahydroborate; methanol / tetrahydrofuran

4.1: pyridine; lithium iodide / 5 h / Reflux

5.1: dmap; N,N-dimethyl-aniline; 1-hydroxy-7-aza-benzotriazole; HATU

5.2: 15 h / 20 °C

With pyridine; methanol; dmap; sodium tetrahydroborate; phosphinic acid; sulfuryl dichloride; 1-hydroxy-7-aza-benzotriazole; sulfuric acid; acetic acid; N,N-dimethyl-aniline; HATU; lithium iodide; sodium nitrite; In tetrahydrofuran; diethyl ether;

Reference yield:

: 1258298-04-2
2-amino-3,5-dichloro-4-(carbomethoxy)benzoic acid methyl ester

: 1415123-73-7
N-{1-[2,6-dichloro-4-(hydroxymethyl)benzoyl]-1H-pyrrolo[3,2-c]pyridin-4-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; sodium nitrite; acetic acid; phosphinic acid

2.1: sodium tetrahydroborate; methanol / tetrahydrofuran

3.1: pyridine; lithium iodide / 5 h / Reflux

4.1: dmap; N,N-dimethyl-aniline; 1-hydroxy-7-aza-benzotriazole; HATU

4.2: 15 h / 20 °C

With pyridine; methanol; dmap; sodium tetrahydroborate; phosphinic acid; 1-hydroxy-7-aza-benzotriazole; sulfuric acid; acetic acid; N,N-dimethyl-aniline; HATU; lithium iodide; sodium nitrite; In tetrahydrofuran;