3-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid methyl ester

Base Information

Chemical Name:3-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid methyl ester
CAS No.:1414378-04-3
Molecular Formula:C₂₀H₁₆Cl₂F₃NO₃S
Molecular Weight:478.319
Hs Code.:

Synonyms:3-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid methyl ester

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Chemical Property of 3-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid methyl ester

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Technology Process of 3-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid methyl ester

There total 5 articles about 3-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.1%

: 1414377-90-4
methyl 3-(3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutanoyl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate

: 1414378-04-3
3-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid methyl ester

Guidance literature:: With hydroxylamine hydrochloride; sodium hydroxide; In methanol; water; at 20 ℃; for 2.5h;

Reference yield: 93.1%

: 1414377-97-1
3-[3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid methyl ester

: 1414378-04-3
3-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid methyl ester

Guidance literature:: 3-[3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid methyl ester; With hydroxylamine hydrochloride; sodium hydroxide; In methanol; water; at 20 ℃; for 2.5h;

With hydrogenchloride; In water; pH=1; Cooling with ice;

Reference yield:

: 765-87-7
cyclohexane-1,2-dione

: 1414378-04-3
3-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium / methanol / 2 h / 0 - 60 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C

3.1: thionyl chloride; pyridine / dichloromethane / 20 °C

4.1: hydroxylamine hydrochloride; sodium hydroxide / water; methanol / 2.5 h / 20 °C

4.2: pH 1 / Cooling with ice

With pyridine; thionyl chloride; hydroxylamine hydrochloride; sodium; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water;