3-((R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-oxopyrrolidin-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxamide

Base Information

Chemical Name:3-((R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-oxopyrrolidin-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxamide
CAS No.:1414378-87-2
Molecular Formula:C₂₃H₂₀Cl₂F₃N₃O₃S
Molecular Weight:546.397
Hs Code.:

3-((R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-oxopyrrolidin-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxamide

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Chemical Property of 3-((R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-oxopyrrolidin-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxamide

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Technology Process of 3-((R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-oxopyrrolidin-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxamide

There total 6 articles about 3-((R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-oxopyrrolidin-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1414377-90-4
methyl 3-(3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutanoyl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate

: 1414378-87-2
3-((R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-oxopyrrolidin-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxamide

: 1414378-89-4
3-((S)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-oxopyrrolidin-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium hydroxide / water; methanol / 2.5 h / 20 °C

2.1: water; lithium hydroxide monohydrate / methanol / 20 °C

2.2: pH 1

3.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.25 h / 20 °C

3.2: 1.5 h / 20 °C

4.1: Chiralcel OD column / carbon dioxide; methanol / Resolution of racemate

With lithium hydroxide monohydrate; hydroxylamine hydrochloride; water; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In methanol; dichloromethane; carbon dioxide; water;

Reference yield:

: 1414378-04-3
3-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid methyl ester

: 1414378-87-2
3-((R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-oxopyrrolidin-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxamide

: 1414378-89-4
3-((S)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-oxopyrrolidin-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; lithium hydroxide monohydrate / methanol / 20 °C

1.2: pH 1

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.25 h / 20 °C

2.2: 1.5 h / 20 °C

3.1: Chiralcel OD column / carbon dioxide; methanol / Resolution of racemate

With lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane; carbon dioxide;

Reference yield:

: 1414378-16-7
3-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid

: 1414378-87-2
3-((R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-oxopyrrolidin-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxamide

: 1414378-89-4
3-((S)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-oxopyrrolidin-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.25 h / 20 °C

1.2: 1.5 h / 20 °C

2.1: Chiralcel OD column / carbon dioxide; methanol / Resolution of racemate

With N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane; carbon dioxide;