N-[2-(1-benzyl-5-methoxy-1H-indol-3-yl)ethyl]-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-[2-(1-benzyl-5-methoxy-1H-indol-3-yl)ethyl]-2,2,2-trifluoroacetamide
CAS No.:1369852-63-0
Molecular Formula:C₂₀H₁₉F₃N₂O₂
Molecular Weight:376.378
Hs Code.:

Synonyms:N-[2-(1-benzyl-5-methoxy-1H-indol-3-yl)ethyl]-2,2,2-trifluoroacetamide

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Chemical Property of N-[2-(1-benzyl-5-methoxy-1H-indol-3-yl)ethyl]-2,2,2-trifluoroacetamide

Chemical Property:

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Technology Process of N-[2-(1-benzyl-5-methoxy-1H-indol-3-yl)ethyl]-2,2,2-trifluoroacetamide

There total 3 articles about N-[2-(1-benzyl-5-methoxy-1H-indol-3-yl)ethyl]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40619-73-6
2-(1-benzyl-5-methoxy-1H-indol-3-yl)ethylamine

: 407-25-0
trifluoroacetic anhydride

: 1369852-63-0
N-[2-(1-benzyl-5-methoxy-1H-indol-3-yl)ethyl]-2,2,2-trifluoroacetamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1055/s-0031-1289656

Reference yield:

: 608-07-1
2-(5-methoxyindol-3-yl)ethylamine

: 1369852-63-0
N-[2-(1-benzyl-5-methoxy-1H-indol-3-yl)ethyl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

1.2: 1 h / 50 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With pyridine; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0031-1289656

Reference yield:

: 100-39-0
benzyl bromide

: 1369852-63-0
N-[2-(1-benzyl-5-methoxy-1H-indol-3-yl)ethyl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

1.2: 1 h / 50 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With pyridine; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0031-1289656