3-[5-(2,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]acrylic acid

Base Information

Chemical Name:3-[5-(2,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]acrylic acid
CAS No.:233604-29-0
Molecular Formula:C₁₃H₁₂N₂O₃
Molecular Weight:244.25
Hs Code.:
Mol file:233604-29-0.mol

Synonyms:(E)-3-[5-(2,5-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]propenoic acid

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Chemical Property of 3-[5-(2,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]acrylic acid

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Technology Process of 3-[5-(2,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]acrylic acid

There total 3 articles about 3-[5-(2,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 233604-27-8
(E)-3-[5-(2,5-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]propenoic acid methyl ester

: 233604-29-0
(E)-3-[5-(2,5-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]propenoic acid

Guidance literature:: With sodium hydroxide; water; In isopropyl alcohol; at 90 ℃;
DOI:10.1055/s-1999-3511

Reference yield:

: 627-63-4
fumaryl dichloride

: 177574-06-0
5-(2,5-Dimethylphenyl)tetrazole

: 233604-29-0
(E)-3-[5-(2,5-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]propenoic acid

Guidance literature:: With 2,3,5-trimethyl-pyridine; In diphenylether; at 95 ℃; for 0.25h;
DOI:10.1055/s-1999-3511

Reference yield:

: 13730-09-1
2,5-dimethylbenzonitrile

: 233604-29-0
(E)-3-[5-(2,5-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]propenoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / NaN₃; NH₄Cl / dimethylformamide / 48 h / 140 °C

2: collidine / diphenyl ether / 0.25 h / 95 °C

With 2,3,5-trimethyl-pyridine; sodium azide; ammonium chloride; In diphenylether; N,N-dimethyl-formamide; 1: Addition / 2: Acylation;
DOI:10.1055/s-1999-3511