methyl 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

Base Information

Chemical Name:methyl 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate
CAS No.:1103930-64-8
Molecular Formula:C₃₃H₃₉N₃O₅
Molecular Weight:557.69
Hs Code.:

Synonyms:methyl 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

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Chemical Property of methyl 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

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Technology Process of methyl 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

There total 4 articles about methyl 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1103930-17-1
methyl 5-bromo-2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]benzoate

: 2-methylpropyl zinc bromide

: 1103930-64-8
methyl 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 2h; Heating / reflux;

Reference yield:

: C₁₂H₁₁BrClNO₅

: 1103930-64-8
methyl 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl acetamide / 1.5 h / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 9 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl acetamide; 2: Negishi coupling reaction;
DOI:10.1248/cpb.59.215

Reference yield:

: 1103930-14-8
(2-{[4-bromo-2-(methoxycarbonyl)phenyl]amino}-2-oxoethoxy)acetic acid

: 1103930-64-8
methyl 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 0 - 20 °C

2: N,N-dimethyl acetamide / 1.5 h / 0 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 9 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; N,N-dimethyl acetamide; 3: Negishi coupling reaction;
DOI:10.1248/cpb.59.215