sodium 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

Base Information

Chemical Name:sodium 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate
CAS No.:1103927-34-9
Molecular Formula:C₃₂H₃₆N₃O₅*Na
Molecular Weight:565.645
Hs Code.:

Synonyms:sodium 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

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Chemical Property of sodium 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

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Technology Process of sodium 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

There total 6 articles about sodium 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1310-73-2
sodium hydroxide

: 1103930-64-8
methyl 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

: 1103927-34-9
sodium 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

Guidance literature:: With water; In tetrahydrofuran; at 50 ℃; for 2h;

Reference yield: 54.0%

: 1103930-64-8
methyl 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

: 1103927-34-9
sodium 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 60 ℃; for 7h;
DOI:10.1248/cpb.59.215

Reference yield:

: 1103930-14-8
(2-{[4-bromo-2-(methoxycarbonyl)phenyl]amino}-2-oxoethoxy)acetic acid

: 1103927-34-9
sodium 2-[({2-[4-(diphenylmethyl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]-5-(2-methylpropyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 0 - 20 °C

2: N,N-dimethyl acetamide / 1.5 h / 0 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 9 h / Reflux; Inert atmosphere

4: sodium hydroxide / tetrahydrofuran; water / 7 h / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl acetamide; water; 3: Negishi coupling reaction;
DOI:10.1248/cpb.59.215