Boc-Tyr-Leu-OBzl

Base Information

• Chemical Name: Boc-Tyr-Leu-OBzl
• CAS No.: 72210-21-0
• Molecular Formula: C27H36 N2 O6
• Molecular Weight: 484.58
• Mol file: 72210-21-0.mol

Synonyms:L-Leucine,N-[N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl]-, phenylmethyl ester

Chemical Property of Boc-Tyr-Leu-OBzl

Chemical Property:

• PSA: 113.96000
• LogP: 4.88410

Purity/Quality:

99% ^*data from raw suppliers

BOC-TYR-LEU-OBZL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boc-Tyr-Leu-OBzl

There total 2 articles about Boc-Tyr-Leu-OBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.4%

Boc-Tyr-OH (3978-80-1) + L-leucine benzyl ester p-toluenesulfonate (1738-77-8) → N-t-butyloxycarbonyl-L-tyrosyl-L-leucine benzyl ester (72210-21-0)

Guidance literature:

With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.jfluchem.2007.12.005

Reference yield: 78.0%

tert-butyl (1-hydrazinyl-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate (23506-20-9) + L-leucine benzyl ester p-toluenesulfonate (1738-77-8) → N-t-butyloxycarbonyl-L-tyrosyl-L-leucine benzyl ester (72210-21-0)

Guidance literature:

With TEA; In N,N-dimethyl-formamide;

Reference yield:

N-t-butyloxycarbonyl-L-tyrosyl-L-leucine benzyl ester (72210-21-0) → Boc-tyrosinyl-leucine (71641-29-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 6h;

DOI:10.1016/j.jfluchem.2007.12.005

upstream raw materials:

tert-butyl (1-hydrazinyl-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate

L-leucine benzyl ester p-toluenesulfonate

Boc-Tyr-OH

Downstream raw materials:

Boc-tyrosinyl-leucine