N-allyl-N-(tert-butoxycarbonyl)-1-phenylbut-3-en-1-ylamine

Base Information

• Chemical Name: N-allyl-N-(tert-butoxycarbonyl)-1-phenylbut-3-en-1-ylamine
• CAS No.: 1289644-06-9
• Molecular Formula: C₁₈H₂₅NO₂
• Molecular Weight: 287.402
• Mol file: 1289644-06-9.mol

Synonyms:N-allyl-N-(tert-butoxycarbonyl)-1-phenylbut-3-en-1-ylamine

Chemical Property of N-allyl-N-(tert-butoxycarbonyl)-1-phenylbut-3-en-1-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-allyl-N-(tert-butoxycarbonyl)-1-phenylbut-3-en-1-ylamine

There total 5 articles about N-allyl-N-(tert-butoxycarbonyl)-1-phenylbut-3-en-1-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + N-allyl-1-phenyl-3-buten-1-amine → N-allyl-N-(tert-butoxycarbonyl)-1-phenylbut-3-en-1-ylamine (1289644-06-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1055/s-0033-1338615

Reference yield:

benzaldehyde (100-52-7) → N-allyl-N-(tert-butoxycarbonyl)-1-phenylbut-3-en-1-ylamine (1289644-06-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1 h / 0 - 20 °C / Neat (no solvent); Inert atmosphere

2: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C / Inert atmosphere

3: tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

In tetrahydrofuran; diethyl ether;

DOI:10.1002/anie.201007133

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + benzylidene allylamine (68003-55-4,21064-27-7) + allylmagnesium bromide (1730-25-2) → N-allyl-N-(tert-butoxycarbonyl)-1-phenylbut-3-en-1-ylamine (1289644-06-9)

Guidance literature:

benzylidene allylamine; allylmagnesium bromide; With diethylzinc; In tetrahydrofuran;

di-tert-butyl dicarbonate;

DOI:10.1021/acscatal.8b02386

upstream raw materials:

di-tert-butyl dicarbonate

benzylidene allylamine

benzaldehyde

1-phenylbut-3-enyl methanesulfonate

Downstream raw materials:

2-phenylpyridine