H-D-Lys(2-CL-Z)-OH

Base Information

• Chemical Name: H-D-Lys(2-CL-Z)-OH
• CAS No.: 201014-19-9
• Molecular Formula: C₁₄H₁₉ClN₂O₄
• Molecular Weight: 314.769
• DSSTox Substance ID: DTXSID30427064
• Mol file: 201014-19-9.mol

Synonyms:201014-19-9;H-D-LYS(2-CL-Z)-OH;Nepsilon-2-Chloro-Z-D-lysine;(2R)-2-amino-6-[(2-chlorophenyl)methoxycarbonylamino]hexanoic acid;(2R)-2-azaniumyl-6-[(2-chlorophenyl)methoxycarbonylamino]hexanoate;(R)-2-Amino-6-((((2-chlorobenzyl)oxy)carbonyl)amino)hexanoic acid;D-Lys(2-Cl-Z)-OH;SCHEMBL3925964;DTXSID30427064;MFCD00190848;AKOS027327864;AS-46856;CS-0208854;F10739;N6-[[(2-Chlorophenyl)methoxy]carbonyl]-D-lysine;(R)-2-Amino-6-((((2-chlorobenzyl)oxy)carbonyl)amino)hexanoicacid;(2R)-2-Amino-6-({[(2-chlorobenzyl)oxy]carbonyl}amino)hexanoic acid

Chemical Property of H-D-Lys(2-CL-Z)-OH

Chemical Property:

• PSA: 101.65000
• LogP: 3.23960
• Storage Temp.: Store at RT.
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 314.1033348
• Heavy Atom Count: 21
• Complexity: 341

Purity/Quality:

99% ^*data from raw suppliers

Ne-2-Chloro-Z-D-lysine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)COC(=O)NCCCCC(C(=O)O)N)Cl
• Isomeric SMILES: C1=CC=C(C(=C1)COC(=O)NCCCC[C@H](C(=O)O)N)Cl

Technology Process of H-D-Lys(2-CL-Z)-OH

There total 4 articles about H-D-Lys(2-CL-Z)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-(S)-Lys(2-Cl-Z)-OH (54613-99-9) → Nε-(2-Chlorophenylmethoxycarbonyl)-(S)-lysine (42390-97-6,201014-19-9)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 0.25h;

DOI:10.1016/j.tetlet.2014.05.090

Reference yield:

phosgene (75-44-5) + 2-Chlorobenzyl alcohol (17849-38-6) + L-Lysine hydrochloride (657-27-2,10098-89-2,26124-78-7) → Nε-(2-Chlorophenylmethoxycarbonyl)-(S)-lysine (42390-97-6,201014-19-9)

Guidance literature:

Multistep reaction; (i) benzene, (ii) /BRN= 3563889/, CuCO₃;

DOI:10.1021/ja00792a047

Reference yield:

2-Chlorobenzyl alcohol (17849-38-6) → Nε-(2-Chlorophenylmethoxycarbonyl)-(S)-lysine (42390-97-6,201014-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 60 h / Ambient temperature

In benzene;

upstream raw materials:

phosgene

2-Chlorobenzyl alcohol

L-Lysine hydrochloride

2-chlorobenzyl chloroformate