(R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzylamino)-N-hydroxyhexanamide

Base Information

Chemical Name:(R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzylamino)-N-hydroxyhexanamide
CAS No.:1043890-17-0
Molecular Formula:C₂₂H₂₉F₂N₃O₂
Molecular Weight:405.488
Hs Code.:

Synonyms:(R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzylamino)-N-hydroxyhexanamide

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Chemical Property of (R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzylamino)-N-hydroxyhexanamide

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Technology Process of (R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzylamino)-N-hydroxyhexanamide

There total 5 articles about (R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzylamino)-N-hydroxyhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1043890-91-0
(R)-methyl 2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzylamino)hexanoate

: 1043890-17-0
(R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzylamino)-N-hydroxyhexanamide

Guidance literature:: With hydroxylamine; potassium cyanide; In tetrahydrofuran; methanol; water; at 20 ℃; for 62h;

Reference yield:

: 342636-66-2
(4-fluoro-3,5-dimethylphenyl)boronic acid

: 1043890-17-0
(R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzylamino)-N-hydroxyhexanamide

Guidance literature:: Multi-step reaction with 4 steps

1: oxygen; copper diacetate; triethylamine / dichloromethane / 87 h / 20 °C / 760.05 Torr / Molecular sieves 4?

2: trifluoroacetic acid / dichloromethane / 19 h / 20 °C

3: sodium tris(acetoxy)borohydride; triethylamine / 1,1-dichloroethane / 63 h / 20 °C

4: hydroxylamine; potassium cyanide / tetrahydrofuran; methanol; water / 62 h / 20 °C

With hydroxylamine; oxygen; potassium cyanide; copper diacetate; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; 1,1-dichloroethane; dichloromethane; water;

Reference yield:

: 1043890-88-5
(R)-6-tert-butoxycarbonylamino-2-(4-fluoro-3,5-dimethylphenylamino)hexanoic acid methyl ester

: 1043890-17-0
(R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzylamino)-N-hydroxyhexanamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 19 h / 20 °C

2: sodium tris(acetoxy)borohydride; triethylamine / 1,1-dichloroethane / 63 h / 20 °C

3: hydroxylamine; potassium cyanide / tetrahydrofuran; methanol; water / 62 h / 20 °C

With hydroxylamine; potassium cyanide; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; 1,1-dichloroethane; dichloromethane; water;