(R)-6-tert-butoxycarbonylamino-2-(4-fluoro-3,5-dimethylphenylamino)hexanoic acid methyl ester

Base Information

• Chemical Name: (R)-6-tert-butoxycarbonylamino-2-(4-fluoro-3,5-dimethylphenylamino)hexanoic acid methyl ester
• CAS No.: 1043890-88-5
• Molecular Formula: C₂₀H₃₁FN₂O₄
• Molecular Weight: 382.476
• Mol file: 1043890-88-5.mol

Synonyms:(R)-6-tert-butoxycarbonylamino-2-(4-fluoro-3,5-dimethylphenylamino)hexanoic acid methyl ester

Chemical Property of (R)-6-tert-butoxycarbonylamino-2-(4-fluoro-3,5-dimethylphenylamino)hexanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-6-tert-butoxycarbonylamino-2-(4-fluoro-3,5-dimethylphenylamino)hexanoic acid methyl ester

There total 1 articles about (R)-6-tert-butoxycarbonylamino-2-(4-fluoro-3,5-dimethylphenylamino)hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(4-fluoro-3,5-dimethylphenyl)boronic acid (342636-66-2) + (R)-2-amino-6-tert-butoxycarbonylaminohexanoic acid methyl ester (63328-49-4,1372256-52-4) → (R)-6-tert-butoxycarbonylamino-2-(4-fluoro-3,5-dimethylphenylamino)hexanoic acid methyl ester (1043890-88-5)

Guidance literature:

With oxygen; copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 87h; under 760.051 Torr; Product distribution / selectivity; Molecular sieves 4?;

Reference yield: 81.0%

(R)-6-tert-butoxycarbonylamino-2-(4-fluoro-3,5-dimethylphenylamino)hexanoic acid methyl ester (1043890-88-5) → (R)-6-amino-2-(4-fluoro-3,5-dimethylphenylamino)hexanoic acid methyl ester (1043890-89-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 19h; Product distribution / selectivity;

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) + (R)-6-tert-butoxycarbonylamino-2-(4-fluoro-3,5-dimethylphenylamino)hexanoic acid methyl ester (1043890-88-5) → C23H28F4N2O2 (1257413-41-4)

Guidance literature:

(R)-6-tert-butoxycarbonylamino-2-(4-fluoro-3,5-dimethylphenylamino)hexanoic acid methyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

4-Trifluoromethylbenzaldehyde; With sodium tris(acetoxy)borohydride; triethylamine; In 1,2-dichloro-ethane; at 20 ℃;

DOI:10.1016/j.bmcl.2010.08.058

upstream raw materials:

(4-fluoro-3,5-dimethylphenyl)boronic acid

(R)-2-amino-6-tert-butoxycarbonylaminohexanoic acid methyl ester

Downstream raw materials:

(R)-6-amino-2-(4-fluoro-3,5-dimethylphenylamino)hexanoic acid methyl ester

C₂₃H₂₈F₄N₂O₂

C₂₃H₂₉F₂N₃O₃

C₂₆H₃₇FN₂O₂