1-(5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)ethanone

Base Information

Chemical Name:1-(5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)ethanone
CAS No.:1376358-77-8
Molecular Formula:C₁₈H₂₂F₃N₃O₂
Molecular Weight:369.387
Hs Code.:

Synonyms:1-(5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)ethanone

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Chemical Property of 1-(5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)ethanone

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Technology Process of 1-(5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)ethanone

There total 3 articles about 1-(5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 657-36-3
4-Trifluormethyl-piperidin

: 1355956-62-5
2-bromo-1-(5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl)ethanone

: 1376358-77-8
1-(5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)ethanone

Guidance literature:: With dmap; potassium iodide; In acetone; for 4h; Heating;
DOI:10.1016/j.ejmech.2012.02.040

Reference yield:

: 90-02-8
salicylaldehyde

: 1376358-77-8
1-(5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium ethanolate / 10 h / 20 - 30 °C

2: hydrazine hydrate / ethanol / 3 h / Reflux

3: 2 h / 40 - 50 °C

4: dmap; potassium iodide / acetone / 4 h / Heating

With dmap; sodium ethanolate; hydrazine hydrate; potassium iodide; In ethanol; acetone;
DOI:10.1016/j.ejmech.2012.02.040

Reference yield:

: 99068-00-5
2-(3-methyl-4,5-dihydro-1H-pyrazol-5-yl)phenol

: 1376358-77-8
1-(5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 2 h / 40 - 50 °C

2: dmap; potassium iodide / acetone / 4 h / Heating

With dmap; potassium iodide; In acetone;
DOI:10.1016/j.ejmech.2012.02.040